Renewable Revolution
Technology => Advances in Health Care => Topic started by: AGelbert on October 13, 2014, 09:06:36 pm
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Fri Oct 10, 2014 at 06:23 AM PDT.
Breakthrough In Path To Diabetes Treatment
by
Richard Lyon
Diabetes is a disorder of carbohydrate metabolism. It is classified into two types I and II. Type I usually occurs in adolescence and is a not well understood process in which the beta cells of the pancreas which produce insulin are completely destroyed. Type II is a collection of related problems which usually involve some combination of insulin production and insulin resistance. People with type I are entirely dependent on injecting insulin to manage their diabetes. Some people with type II reach a point at which they also need to inject insulin. The holy grail of diabetes treatment has long been the hope for a means of replacing beta cells. Now researchers at Harvard have taken a giant step along the road toward achieving that goal.
Type 1 diabetes breakthrough using stem cell research raises hope for cure Experts at Harvard University use stem cells to create insulin-producing beta cells in large quantities, and say human transplantation trials could be under way within a few years
Scientists believe they have made a major advance in the quest to find an effective treatment for type 1 diabetes.
Using human embryonic stem cells as a starting point, they have for the first time been able to create human insulin-producing beta cells equivalent in almost every way to normally functioning beta cells in the kind of large quantities needed for cell transplantation and pharmaceutical purposes. (https://renewablerevolution.createaforum.com/proxy.php?request=http%3A%2F%2Fwww.createaforum.com%2Fgallery%2Frenewablerevolution%2F3-200714194256.bmp&hash=1c2795e25df0dc7d9be4879b7bba6f1632f715e1)
“[While] there have been previous reports of other labs deriving beta cell types from stem cells, no other group has produced mature beta cells as suitable for use in patients,” he said.
“The biggest hurdle has been to get to glucose-sensing, insulin-secreting beta cells, and that’s what our group has done.
“We are now just one pre-clinical step away from the finish line.”
As part of the research they have developed a device to protect the transplanted beta cells from immune attacks by the body of the recipient. It has proved to be effective in mice. At present there are experimental cell transplant treatments for humans using cells from cadavers. They require heavy dosages of immunosuppressive drugs. They have not proven feasible for general clinical application.
This is one of a number of areas in which the use of stem cells offers great prospects for regenerative medicine.
This form of beta cell transplant is not going to be available in the immediate future. However, it does appear to offer real hope for people down the road.
Originally posted to Richard Lyon on Fri Oct 10, 2014 at 06:23 AM PDT.
Also republished by SciTech and KosAbility.
http://www.dailykos.com/story/2014/10/10/1335636/-Breakthrough-In-Path-To-Diabetes-Treatment
Agelbert NOTE: You DO NOT require aborted fetuses to get stem cells, PERIOD! That "hurdle" was passed nearly a DECADE ago! (https://renewablerevolution.createaforum.com/proxy.php?request=http%3A%2F%2Fwww.pic4ever.com%2Fimages%2F301.gif&hash=0291ed4abf2d80e420d1aa00d4eb3c5dd6bbfb53)
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The Truth About Artificial Sweeteners (https://renewablerevolution.createaforum.com/proxy.php?request=http%3A%2F%2Fwww.freesmileys.org%2Femoticons%2Femoticon-object-070.gif&hash=93009ff65ce639d8cd1cdf1ed3e8c37e93940a2c)
Joe Leech, Authority Nutrition
http://ecowatch.com/2014/11/25/truth-artificial-sweeteners/
Agelbert comment: Great article!
From my point of view and experience, I think it is prudent to not "fake out" our taste buds with artificial anything. The body is a complex mechanism. It talks to us. Why do we want to fool it? Moderation is healthy. Everyone knows that. Pigging out isn't. Everyone knows that too. You can die from drinking too much WATER! Same with eating too much of ANYTHING that is required for us to live and thrive. We function in a narrow band of temperature, pH, oxygen concentration, ETCETERA. Trying to "cheat" that band is stupid as well as irrational.
Only in the deranged predatory capitalist minds of the Wall Streeters that curse this country is a destructive force considered "Creative". This is nothing but the cheater's manual of Orwellian (see 1984) "logic".
Metabolic events resulting from what we eat are either destructive OR Creative but NEVER both! Required nutrients are creative and life giving as long as they are consumed in a NARROW band that defines our needs. If you go outside that band, they become DESTRUCTIVE. Sugar, for example, is a killer in excessive (and refined - i.e. no fiber or moderating nutrients and minerals as those in a fruit) quantities.
Let's GET OVER this, "take a pill" to solve our piggery from artificial sweeteners to every sort of stupid excess we engage in. If we do the crime, we MUST do the "time" (i.e. cancer or other disease). Our bodies ARE NOT fooled, even if our minds have bought into Wall Street magical thinking.
TINA to a Low Carbon Economy (http://renewablerevolution.createaforum.com/climate-change/global-warming-is-with-us/msg2114/#msg2114)
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https://www.youtube.com/watch?v=lEXBxijQREo&feature=player_embedded
How Sugar makes a Dopamine Dope Out of YOU! :P
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Mon Jun 08, 2015 at 03:53 PM EDT.
100-year-old vaccine wins FDA approval for human clinical trials to reverse Type 1 diabetes (https://renewablerevolution.createaforum.com/proxy.php?request=http%3A%2F%2Fwww.createaforum.com%2Fgallery%2Frenewablerevolution%2F3-200714191456.bmp&hash=a239c2fd76d20d142f1c54b961e22ebd0d2a4808)
by
Jen Hayden
Is a drug to reverse diabetes in our future?
This is amazing! (https://renewablerevolution.createaforum.com/proxy.php?request=http%3A%2F%2Fwww.desismileys.com%2Fsmileys%2Fdesismileys_0293.gif&hash=b1af4868ed8f18c30e637f8cbcb79002f6f71039) A 100-year-old vaccine for tuberculosis has been so successful at controlling Type 1 diabetes that it's won FDA approval:
Scientists at Massachusetts General Hospital are hoping to prove that type 1 diabetes can be reversed with the help of a generic drug.
The five-year long, phase II clinical trial, which received approval from the U.S. Food and Drug Administration, was announced Sunday during the 75th Scientific Sessions of the American Diabetes Association, one of the largest diabetes gathering in the country.
Scientists have already tested the bacillus Calmette-Guerin vaccine in mice, showing the drug’s ability to eliminate abnormal white blood cells responsible for the autoimmune disease.
The drug now moves on to the next phase of clinical trials:
Now, the FDA has approved a trial of 150 adults age 18 to 60 with long-term Type 1 Diabetes, an autoimmune disease usually diagnosed in children and young adults.
Good news for the roughly 29 million Americans and 387 million worldwide who suffer from the disease.
http://www.dailykos.com/story/2015/06/08/1391599/-100-year-old-vaccine-wins-FDA-approval-for-human-clinical-trials-to-reverse-Type-1-diabetes