Posted by: AGelbert« on: April 21, 2017, 09:00:21 pm »
The African naked mole-rat can keep its brain alive for more than 5 hours with no oxygen
Last updated on April 21st, 2017 at 2:30 pm by Alexandru Micu
There’s no metabolic tweak that would make them less ugly though.
Image credits Thomas Park / UIC.
Image credits Thomas Park / UIC.
You know what would really ruin your day? A lack of oxygen.
But that’s only because we’re humans and not the awesome Heterocephalus glaber or African naked mole-rat. Individuals of this species are used to living jam-packed with hundreds of their kin in small, poorly-ventilated burrows — where the oxygen-o-meter often falls below breathable levels. So the hairless critters have evolved to counteract this by copying a part of the plant metabolism. Understanding how their bodies do this could open the way to treatments for patients suffering crises of oxygen deprivation, as in heart attacks and strokes.
“This is just the latest remarkable discovery about the naked mole-rat — a cold-blooded mammal that lives decades longer than other rodents, rarely gets cancer, and doesn’t feel many types of pain,” says Thomas Park, professor of biological sciences at the University of Illinois at Chicago and lead author of the study.
The team exposed naked mole-rats to low oxygen conditions in lab settings, and subsequently found high concentrations of fructose in their bloodstream. This compound was shuttled to neurons via molecular fructose pumps which are only used in the intestine walls of all other mammal species. Park’s team reports that when oxygen levels fall, the naked mole-rats’ brain cells begin metabolizing fructose, a process which releases energy without needing any oxygen. Up to now, this metabolic pathway was only documented in plants — so finding it in the moles was a big surprise.
Fructose metabolism allows the moles to live more than five hours through oxygen levels low enough to kill a human in minutes. Since only their brains are kept at full power by the compound, the moles enter a state of suspended animation in which they exhibit drastically reduced movement and a much lower pulse and breathing rate to save up on energy. It’s the only mammal known to use a suspended-animation state to power through oxygen deprivation.
They’re also seemingly immune to pulmonary edemas — the buildup of fluid which clogs the lungs of mammals in low-oxygen environments, such as climbers at high altitude.
“The naked mole-rat has simply rearranged some basic building-blocks of metabolism to make it super-tolerant to low oxygen conditions,” park adds.
The full paper “Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat” has been published in the journal Science.
Agelbert NOTE: The claim that the naked mole rate "evolved" this ability to survive without oxygen is an assumption lacking evidence.
Until they PROVE that, at one time, the metabolism of Heterocephalus glaber did NOT have this ability coded into it's DNA as a potential ADAPTATION from the ORIGINAL DNA package, it is irresponsible, as well as scientifically inaccurate, to equate adaptation with evolution.
They also need to prove that Heterocephalus glaber burrow populations were once well ventilated or/and had small populations not requiring this ability.
Scientists would have to document the DNA genome difference when the moles obtained that ability. If there is NO DNA difference, there is NO evolution.
A gene coding sequence that is dormant and gets triggered by environmental conditions is NOT a change in the package and is called ADAPTATION, not Evolution.
Natural Selection is a SUBTRACTIVE process. There is NO evidence that Natural Selection is an additive process.
Rant follows after a simplistic, reductionist video ("allegations of harm by some technology are scientifically invalid bullshit if you personally cannot test the hypothesis") made by an Evolution True Believer that distorts the scientific method AND completely avoids the mention of the Precautionary Principle of Science.
There are many occasions in our lives when a hypothesis cannot be tested. However, the Precautionary Principle of science dictates that a potentially harmful activity, such as vaccination, burning fossil fuels, hormone disrupting chemicals from chemical plant pollutants, ETC. must NOT be allowed to continue.
Also, Evolution is not considered BS, but, so far (and believe me, they have tried FOR OVER 20 YEARS with an ongoing E. Coli experiment to see when they "evolve" WITHOUT SUCCESS), they have not been able to test the hypothesis OR obtain any reproducibility in regard to evolution.
Nevertheless, every single competing theory has been discarded BY THE SCIENTIFIC COMMUNITY as being "unscientific"...
Have you heard about the scientific community consensus that, because the Fibonacci ratio, and a few more sine qua non conditions required for life in our universe, are totally NON-RANDOM, we therefore must be inhabiting a matrix, rather than a universe created by a Supreme Being (i.e. God). So what happened to Occam's razor THERE, huh?
And spare me the six day creation mockery. The Bible is not a science book!
But Fibonacci down to the QUANTUM LEVEL is evidence of a creator, not a matrix.
Now you can claim we are just a randomly perfect universe in an endless amount of lifeless universes. AGAIN, you discard Occam's Razor and reach for your Atheist endowment bias. And then you claim you don't believe BS. LOL!
Someday, when scientists decide to stop confusing ADAPTATION from a pre-existing DNA package with "evolution", the evolutionists will stop believing in Bullshit. Natural Selection is a SUBTRACTIVE process in complex organisms, despite the ability of bacteria to take up plasmids randomly and mutate. The "bacteria mutated to become complex organisms" dog won't hunt in ANY serious use of the Scientific Method, simply because you CANNOT TEST THAT HYPOTHESIS.
The hypothesis that "Natural Selection is a subtractive Process" HAS BEEN TESTED. Why do you evolutionists refuse to accept the Scientific Method RESULTS?
Have a nice day.