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Topic Summary

Posted by: AGelbert
« on: November 13, 2018, 01:30:44 pm »

 CANCER TODAY
Practical Knowledge. Real Hope.
from the American Association for Cancer Research


September 25, 2018

New Tactics for Bladder Cancer

After decades without treatment advances, options for patients with bladder cancer are now more numerous. 👍

by Kendall K. Morgan

WHEN KARL PRITCHARD noticed blood in his urine one morning in February 2014, he made an appointment with his primary care d​octor. The doctor told Pritchard, who was 76 years old at the time, that if he didn’t have a bladder infection, the blood was probably a sign of cancer.

When a course of antibiotics didn’t resolve the issue, the doctor ordered a CT scan and had his office schedule an appointment with a urologist near Pritchard’s home in Edenton, North Carolina. The urologist performed a cystoscopy, threading a small tube with a light and lens through the urethra and into the bladder, which revealed a tumor. The specialist surgically removed a sample of tumor tissue that included the inner wall of the bladder and its underlying muscle. The biopsy results and CT scan indicated the cancer was boring its way into the muscle layer of the bladder wall.    

 ...

Bladder cancer survivor Karl Pritchard enrolled in a clinical trial for a PD-L1 inhibitor prior to its approval by the U.S. Food and Drug Administration for treating bladder cancer. He currently has no evidence of disease. Photo by Ed Cunicelli, © 2016 Cancer Support Community

Within weeks, Pritchard had robotic surgery to remove his bladder. After pathology reports came back, he was diagnosed with stage III urothelial carcinoma. Urothelial cancer is the most common type of bladder cancer in the U.S., and the standard treatment for Pritchard’s type of cancer includes surgery and the chemotherapy drug cisplatin. However, during Pritchard’s operation, the surgeon discovered the tumor had damaged his left kidney by blocking blood flow to the ureter, a duct that transports urine from the kidney to the bladder. His right kidney was also damaged due to a complication from surgery.

The compromised kidney function made Pritchard ineligible for chemotherapy, which for decades had been the only drug option approved by the U.S. Food and Drug Administration (FDA) for invasive bladder cancer. The kidneys are essential for ridding the body of waste products, including chemotherapy drugs. While the treatment might have helped keep the cancer at bay, it would have almost certainly done further damage to the kidneys. It wasn’t worth the risk.

At the time, “the only thing I knew about cancer was how to spell it,” Pritchard says. He resolved to pore over everything he could find about bladder cancer. In an internet search, he stumbled across what sounded like a promising experimental option: immunotherapy drugs known as checkpoint inhibitors.

Immunotherapy treatments enlist the immune system in the fight against cancer. In 2011, the checkpoint inhibitor Yervoy (ipilimumab), which inhibits a protein known as CTLA-4, was approved to treat patients with metastatic melanoma. In the same year that Pritchard received his diagnosis, two immunotherapy treatments, which are part of a class of drugs known as PD-1 and PD-L1 inhibitors, received FDA approval for metastatic melanoma. PD-1 is found at the surface of immune cells, and PD-L1 can be found in abundance in some types of cancer. When these two proteins bind, the immune cells are unable to attack the cancer cells. By blocking either PD-1 or PD-L1 and thereby preventing the interaction between them, this class of checkpoint inhibitor releases the “brakes” on the immune system, allowing the body to go full throttle against cancer.

But these drugs were years away from approval for treating bladder cancer when Pritchard asked in May 2014, soon after his operation, whether immunotherapy might be an option for him. His surgeon responded that he should get his affairs in order. Despite the surgical removal of Pritchard’s bladder, a PET scan later showed cancer in his pelvis and lymph nodes in his abdomen, glowing “like headlights in a dark room,” Pritchard says.


Overcoming the Odds

In the U.S., about 80,000 people will receive a diagnosis of bladder cancer this year, and more than 700,000 people are now living with the disease. About 75 percent of people diagnosed with bladder cancer live at least five years after their diagnosis. That’s because most bladder cancers are caught in the early stages, when the cancer is only in the inner lining of the bladder. Once the cancer invades the surrounding deep muscle or spreads to nearby lymph nodes, the patient’s chances of survival drop precipitously. Pritchard’s inability to undergo treatment left him in an even more tenuous position.

Despite the long odds, Pritchard wasn’t ready to give up. He asked his oncologist the same question he had asked the surgeon: What about immunotherapy? As luck would have it, his oncologist’s office was affiliated with another office based in Norfolk, Virginia, that was recruiting patients for a clinical trial to analyze a checkpoint inhibitor called Tecentriq (atezolizumab) for advanced bladder cancer. Pritchard visited the Norfolk office and had a sample of his previously frozen bladder tissue sent off for analysis for the study. Because his tumor expressed high levels of PD-L1 and he was not a candidate for chemotherapy, he was eligible to enroll in the trial.

He received his first infusion of Tecentriq in February 2015, joining the study along with 118 other patients with locally advanced or metastatic bladder cancer for whom chemotherapy wasn’t an option. He began receiving infusions of the drug every three weeks at the Norfolk clinic, 70 miles from his home. Scans, taken every other month, first showed the tumors shrinking dramatically and then indicated no evidence of cancer.

Pritchard was fortunate. The study results from the trial arm he participated in showed that just about 20 percent of patients with otherwise untreatable bladder tumors responded to the immunotherapy treatment. About 25 percent of patients whose tumors had high levels of PD-L1 expression responded. In May 2016, the FDA approved Tecentriq to treat advanced or metastatic urothelial carcinoma that hasn't responded to platinum-based chemotherapy, making it the first PD-1 or PD-L1 inhibitor approved to treat the disease. In April 2017, the FDA extended the drug’s approval as a first-line treatment for people with locally advanced or metastatic urothelial carcinoma who aren’t eligible for treatment with cisplatin.

The FDA has now approved four additional checkpoint inhibitors for bladder cancer: Bavencio (avelumab), Imfinzi (durvalumab), Keytruda (pembrolizumab) and Opdivo (nivolumab). Surgery and chemotherapy are still considered the standard of care for bladder cancer. However, patients on chemotherapy whose cancer progresses or who, like Pritchard, are unable to receive chemotherapy for other reasons now have viable treatment alternatives. ​​

Detecting Bladder Cancer

Researchers explore using urine tests to monitor patients for signs of recurrence.

​Research on the Rise

The number of clinical trials in bladder cancer has grown since the time of Pritchard’s diagnosis in 2014. For example, a recent search using ClinicalTrials.gov, an online repository of research trials, shows more than 260 studies are enrolling patients with bladder cancer.

Researchers are exploring the use of combinations of immunotherapies or immunotherapy plus chemotherapy. For instance, a team led by researchers at the Icahn School of Medicine at Mount Sinai in New York City recently reported the results of a phase II clinical trial showing that metastatic bladder cancer patients, especially those whose tumors carry DNA repair defects, may benefit from receiving the chemotherapy drugs gemcitabine and cisplatin together with Yervoy. A phase II tr​ial set to begin in September 2018 is analyzing this chemotherapy combination plus Opdivo in patients with muscle-invasive bladder cancer.

There is also interest in combining existing checkpoint inhibitors with IDO inhibitors, which target other proteins shown to help cancer escape the immune system. (Of note, however, a phase III clinical trial testing​ this combination approach in melanoma recently ended in failure.) In March 2018, the FDA granted breakthrough therapy designation to a drug called enfortumab vedotin, which means the agency is expediting its development and review, for use in patients with locally advanced or metastatic bladder cancer who have previously received checkpoint inhibitors. The treatment, while not an immunotherapy, targets a protein called nectin-4 that’s highly expressed in most metastatic bladder cancers. One study found that about 50 percent of patients with metastatic urothelial carcinoma responded to the treatment.

Researchers are also looking into combining chemotherapy with drugs targeting a blood vessel growth factor called VEGF. In addition, a phase II​​ clinical​ trial recently showed that about 40 percent of patients whose metastatic urothelial cancers carry mutations in the FGFR3 gene respond to treatment with an oral drug called erdafitinib, which also received the FDA’s breakthrough therapy designation for metastatic bladder cancer in March 2018. The drug targets all FGFR proteins, including the mutated FGFR3 found in as much as 20 percent of metastatic bladder cancers. Researchers are also exploring whether epigenetic drugs, some of which can chemically alter the surface of DNA to influence gene expression, might reinvigorate a response to immunotherapy after it stops working.

“As a urologist who has been involved in clinical trial research for the last 20 years, it’s been very rewarding to see in the last two to three years, and certainly now, a renewed awakening in the bladder cancer clinical trials landscape,” says Neal Shore, a urologic oncologist and director of the Carolina Urologic Research Center in Myrtle Beach, South Carolina. “For almost three decades, we didn’t have a lot to be excited about, and now we have a lot of really interesting clinical trials with different molecules targeting different molecular pathways.”

Matching Treatments to Patients

With all the emerging choices, researchers also are focusing on finding biomarkers to couple the most promising treatment option with a patient’s unique tumor genetics. With a better understanding of how specific markers make the cancer behave, “you could not only detect the cancer, but pinpoint how to treat it,” says David McConkey, a research scientist and director of the Johns Hopkins Greenberg Bladder Cancer Institute in Baltimore. “My vision is that some patients will be assigned pre-surgical chemotherapy and some pre-surgical immunotherapy—maybe some will be assigned to receive both at same time,” McConkey says.

The Cancer Genome Atlas, a comprehensive project by the National Cancer Institute to categorize the DNA changes in various cancer types, recently analyzed tissue samples of more than 400 muscle-invasive bladder tumors, McConkey notes. This research has uncovered 58 significantly mutated genes and five distinct molecular subtypes of bladder cancer, which could aid in pairing treatments with the genetics of a patient’s tumor. But there’s more work to be done.

“In the future, we’re going to have to learn about the biology of a tumor and make decisions based on that biology, and everybody will be different,” says Matthew Milowsky, a urologic oncologist at the University of North Carolina at Chapel Hill. Milowsky is leading a study sponsored by the Bladder Cancer Advocacy Network that provides free genomic testing to patients with metastatic bladder cancer to help identify the most promising clinical trials and to develop a tissue repository for future research.

In many cases, this kind of molecular characterization is already guiding treatment choices for patients with bladder cancer, but it’s not being used everywhere, Milowsky cautions. An important question will be “how do we translate such efforts” to reach more people, the majority of whom receive care in community health care settings.

Fortunately, Pritchard asked about immunotherapy and found a path to a clinical trial that would ultimately extend his life. He still goes in for regular blood draws and infusions of Tecentriq every three weeks as part of the ongoing clinical trial. There is no evidence of cancer in his body, but he continues to search the web daily to learn about new treatments. And even though Pritchard is unable to lift more than 25 pounds because of his surgery and he tires easily—a common side effect of immunotherapy treatment—he says his quality of life is “still very good.”​

For others who find themselves in a similar position, he has some advice: “Doctors see so many patients each day and can’t remember all the details. As a patient, you need to speak up for yourself.” Ask questions, he says, and, if you aren’t satisfied with the response, keep asking until you are. ​

https://www.cancertodaymag.org/Pages/Fall2018/New-Tactics-for-Bladder-Cancer.aspx
Posted by: AGelbert
« on: December 02, 2017, 04:48:48 pm »

The Tax Scam Passed the Senate. What Now?

December 2, 2017

Republicans have jammed the Trump Tax Scam through the Senate, by a vote of 51-49. It’s hard to imagine how this bill could be worse: not only does it give massive tax cuts to the rich and corporations, it also allows drilling in the Arctic National Wildlife Reserve, exacerbates growing inequality, and adds $1 trillion to the deficit—which will force deep cuts to Medicaid, Medicare, and Social Security down the road.

The Tax Scam is not yet law. Republicans have two options for how to get the Tax Scam across the finish line, and then they have to immediately attend to funding the government. Here’s what comes next.

OPTION A: “GO TO CONFERENCE”

Since the House and Senate passed different versions of the Tax Scam, one option for Republicans is to merge them together by “going to conference.” This is where members of the House and Senate are appointed to a conference committee.  The goal is to work out the differences between the bills and put them together into one “conference report” which is then voted on by both the House and Senate.

There are a number of important differences between the two bills, first and foremost the repeal of the individual mandate that was included in the Senate version but not the House. There are also differences between the individual tax rates, the estate tax, and the alternative minimum tax.

Republicans have all publicly ;)  said they want to go to conference. Going to conference would more closely resemble “regular order” and allow for some review of what is in these bills. That extends the process of passing the Tax Scam by at least two weeks or so, because they have to appoint conferees, come up with the agreement, and then vote on it in both chambers. Given the deep unpopularity of the Tax Scam, it’s likely they’ll try to avoid conference at any cost by instead choosing Option B…

OPTION B: THE HOUSE PASSES THE SENATE BILL—AS IS

To really put the pedal to the metal on finishing the Tax Scam, Republicans can instead have the House pass the version just passed by the Senate. Even though Republicans have all said they want to go to conference, it would save them a ton of time and trouble to go this route instead. If the votes are there in the House to pass the Senate bill, they will.

Look for Speaker Ryan to quietly spend the weekend twisting arms behind the scenes. There is currently a vote scheduled on Monday, December 4 to “instruct conferees” (tell the members of the Conference Committee what to do)—but this could easily be turned into a vote on the Senate bill itself if the votes are there.

TURNING TO GOVERNMENT FUNDING AND DREAM

If Republicans go with Option A, it will mean the conference report on the Tax Scam takes a back seat to next week’s main event: finding a way to fund the government by the December 8 deadline. If they go with Option B, and the bill passes the House, it will mean Congress has finished its work on the Tax Scam.

Either way, our attention now needs to be on funding the government and holding Democrats to their commitment to secure inclusion of the DREAM Act in the funding bill. Democrats have promised for three months that they will use their leverage on the December spending bill to get the DREAM Act done. Now it’s time for them to deliver. Read more and find out how you can help Dreamers at www.dreamerpledge.org.

https://www.trumptaxscam.org/what-now

Nothing in this tax plan benefits anyone as far down the food chain as I am. I noticed that (as usual) that doctors and lawyers are explicitly denied the corporate tax loopholes, as has been the case for decades now. Bend over, citizens.

Yep.  :(

Thank you for this info. People need to know that even a professional like you with a degree in medicine is not going to benefit in comparison with the elite crooks this Tax Scam was pushed through for.

By the way, if you have the time, check out the video and the article I just posted. There is some fascinating new info on metabolic activity. For example, you and I were taught that the brain gets energy exclusively from glucose metabolism. It turns out that is not true. Ketone metabolism has been found to inhibit all sorts of deleterious activity like siezures and ischemic conditions. It's really strange because it turns out too much oxygen (study of U.S. Navy divers) caused seizures and ALSO anoxic condition ischemia and metabolic disease conditions can both be treated with ketone therapy. It's a bit involved for the average joe but you have all the years of study to understand this. It seems like a great avenue for improved health. If you find any flaws that they don't mention (e.g. ketosis downsides for our health), please fill me in.
Posted by: AGelbert
« on: December 02, 2017, 04:21:38 pm »

Agelbert NOTE: Did you know that ALL cancer cells (from ALL types of cancers) have mitichondrial dysfunction? Healthy mitochondria are the ultimate cancer cell suppressors. The importance of that fact for your health goes beyond cancer prevention to metabolic disease prevention and/or therapy.

How Metabolic Therapies Prevent and Treat Chronic Diseases

December 02, 2017 • 116,071 views   
 

Story at-a-glance

Quote
֍ Mounting evidence shows conditions such as Alzheimer’s and cancer are metabolic diseases, which means you can prevent, treat and recover from them like other metabolic conditions, such as Type 2 diabetes and heart disease

֍ A number of experts and researchers are now convinced the answer to our burgeoning cancer and Alzheimer’s epidemics is a ketogenic diet and other metabolic support, such as fasting, hyperbaric oxygen treatment and dietary supplementation

֍ During fasting or ketosis, your brain switches to using ketone bodies derived from dietary fats as its primary fuel, and ketones have potent neuroprotective effects and enhance brain function

֍ Healthy cells have the metabolic flexibility to use either glucose or ketones (obtained through your diet from carbohydrates and healthy fats respectively), whereas cancer cells cannot use ketones for fuel due to having damaged mitochondria

֍ Nutritional ketosis prevents and combats cancer by optimizing mitochondrial function, decreasing blood glucose and insulin, increasing tissue oxygenation, decreasing free radical generation, downregulating oncogenes and upregulating tumor suppressor genes

Detailed article with more video:

https://articles.mercola.com/sites/articles/archive/2017/12/02/metabolic-therapy.aspx
Posted by: AGelbert
« on: January 06, 2017, 06:43:05 pm »


Medicine That Grows On Trees  ;D

David Wolfe, a leading authority on nutrition and raw food, points out the value of a simple mushroom growing on a tree stump.

 In these mushrooms is where you will find some of the strongest medicinal compounds.

 He shows us the cloud mushroom, so common it grows in every state of the US and Canada.

 It has tremendous healing properties: immune system enhancing and anti-cancer properties, and it detoxifies the liver not only of cancer causing agents but of plastic by-products!

 If you learn to identify it, you can simply harvest this mushroom, take it home and make a healing tea.

 --Bibi Farber

 This video was produced by 21daystohealth.com

http://www.nextworldtv.com/videos/health-and-wellness/healing-with-wild-mushrooms-.html
Posted by: AGelbert
« on: November 20, 2015, 12:14:37 am »

Making an informed decision requires being informed. Are you?   

 In the United States, cancer kills six hundred thousand people each year. Like most wars, the 'war' on cancer is expensive, and profitable. In that one year, chemotherapy will generate almost $100,000,000,000 (one hundred billion) of income.

 Chemotherapy is effective against certain types of cancer (leukemia, lymphoma/Hodgkin's), which, taken together, make up a fraction of all-cancer mortality (<1%). For the major metastatic cancer killers however (breast, lung, colon, pancreatic), five-year survival rates have not changed significantly since the advent of its widespread use. Its side effects are associated with significant morbidity and even further carcinogenesis (aka more costs/profits). One might wonder what happened to the Hippocratic Oath.

 Chemotherapy costs $50,000-$70,000 or more per treatment regimen. Unlike any other prescription drug or treatment, doctors prescribing chemo make direct profit per sale.

 And despite what most oncologists have been taught, if you are taking radiation or chemo, or both, ...take your anti-oxidants also. You're more likely to get better, with fewer and less severe side effects.

Be informed.
- See more at: http://www.nextworldtv.com/videos/health-and-medical-2/chemotherapy---its-good-for-whom.html#sthash.pbaej7SW.dpuf
Posted by: AGelbert
« on: May 19, 2015, 12:40:55 am »

Why Can't Naked Mole Rats Get Cancer?   

According to a study done by the University of Rochester in 2013, naked mole rats do not get cancer because they have complex sugars that prevent cells from clumping and turning into cancerous tumors.

Naked mole rats were selected for the study because they live very long, about 30 years, and do not seem to get cancer. The study revealed that the reason cells do not clump in naked mole rats is due to a complex sugar called hyaluronan in the extracellular matrix, the space between cells.



The study set off discussions about the possibility of altering hyaluronan sugars in humans or using this specific gene from naked more rats in the fight against cancer.

More about naked mole rats:


•The naked mole rat is a type of rodent which lives in burrows in soil. It spends most of its life in darkness.

•Contrary to popular belief, naked mole rats are not blind and they are not exactly hairless; they have very thin hairs that help them with navigation.



•Naked mole rats have a social structure similar to some insects. There are worker and fighter naked mole rats, and a queen who is the only one who breeds.


http://www.wisegeek.com/why-cant-naked-mole-rats-get-cancer.htm
Posted by: AGelbert
« on: April 05, 2015, 12:37:51 am »

One dollar blood test  :o  ;D using gold nanoparticles outperforms PSA screen for prostate cancer, study suggests

Date: April 3, 2015

Source: University of Central Florida


Dr. Qun "Treen" Huo of UCF's NanoScience Technology Center has developed a prostate cancer test using gold nanoparticles. Pilot studies found it to be more accurate than the standard PSA test.

Credit: Image courtesy of University of Central Florida

A test that costs less than a $1 and yields results in minutes has been shown in newly published studies to be more sensitive and more exact than the current standard test for early-stage prostate cancer.

The simple test developed by University of Central Florida scientist Qun "Treen" Huo holds the promise of earlier detection of one of the deadliest cancers among men. It would also reduce the number of unnecessary and invasive biopsies stemming from the less precise PSA test that's now used.

"It's fantastic," said Dr. Inoel Rivera, a urologic oncologist at Florida Hospital Cancer Institute, which collaborated with Huo on the recent pilot studies. "It's a simple test. It's much better than the test we have right now, which is the PSA, and it's cost-effective."

When a cancerous tumor begins to develop, the body mobilizes to produce antibodies. Huo's test detects that immune response using gold nanoparticles about 10,000 times smaller than a freckle.

When a few drops of blood serum from a finger prick are mixed with the gold nanoparticles, certain cancer biomarkers cling to the surface of the tiny particles, increasing their size and causing them to clump together.

Among researchers, gold nanoparticles are known for their extraordinary efficiency at absorbing and scattering light. Huo and her team at UCF's NanoScience Technology Center developed a technique known as nanoparticle-enabled dynamic light scattering assay (NanoDLSay) to measure the size of the particles by analyzing the light they throw off. That size reveals whether a patient has prostate cancer and how advanced it may be.

And although it uses gold, the test is cheap. A small bottle of nanoparticles suspended in water costs about $250, and contains enough for about 2,500 tests.

"What's different and unique about our technique is it's a very simple process, and the material required for the test is less than $1," Huo said. "And because it's low-cost, we're hoping most people can have this test in their doctor's office. If we can catch this cancer in its early stages, the impact is going to be big."

After lung cancer, prostate cancer is the second-leading killer cancer among men, with more than 240,000 new diagnoses and 28,000 deaths every year. The most commonly used screening tool is the PSA, but it produces so many false-positive results -- leading to painful biopsies and extreme treatments -- that one of its discoverers recently called it "hardly more effective than a coin toss."

Pilot studies found Huo's technique is significantly more exact. The test determines with 90 to 95 percent confidence that the result is not false-positive. When it comes to false-negatives, there is 50 percent confidence -- not ideal, but still significantly higher than the PSA's 20 percent -- and Huo is working to improve that number.

The results of the pilot studies were published recently in ACS Applied Materials & Interfaces. Huo is also scheduled to present her findings in June at the TechConnect World Innovation Summit & Expo in suburban Washington, D.C.

Huo's team is pursuing more extensive clinical validation studies with Florida Hospital and others, including the VA Medical Center Orlando. She hopes to complete major clinical trials and see the test being used by physicians in two to three years.

Huo also is researching her technique's effectiveness as a screening tool for other tumors.

"Potentially, we could have a universal screening test for cancer," she said. "Our vision is to develop an array of blood tests for early detection and diagnosis of all major cancer types, and these blood tests are all based on the same technique and same procedure."

Huo co-founded Nano Discovery Inc., a startup company headquartered in a UCF Business Incubator, to commercialize the new diagnostic test. The company manufacturers a test device specifically for medical research and diagnostic purposes.

http://www.sciencedaily.com/releases/2015/04/150403130826.htm

Agelbert NOTE:      HMMMMmmmm....  GOLD for detecting PROSTATE CANCER... There's got to be a good joke in there somewhere.   

Posted by: AGelbert
« on: July 31, 2014, 02:30:39 am »

Posted by: AGelbert
« on: July 04, 2014, 08:10:15 pm »

Does Sugar Overconsumption Really Cause Cancer and Contribute to Heart Disease? ???

Sugar overconsumption might cause cancer and contribute to heart disease, research suggests. This is thought to be the result of extra stress put on the body during the metabolizing of fructose, or the sugar found in certain plants. Unlike the carbohydrates found in vegetables and starches that are metabolized by all of the body’s cells, fructose is metabolized only by the liver. The increase in metabolizing blood sugar is thought to cause the cell mutations that result in cancer and raise the levels of triglycerides, or fat, in the bloodstream, which can cause heart disease.

More about sugar:

•The average American is estimated to consume about 90 pounds (40.82 kg) of sugar each year.

•There are about 10 teaspoons (40 g) of sugar in an average can of soda, which is nearly twice the amount of sugar that health experts recommend consuming in a day.

•Lower-income people consume the most calories from sugar, at roughly 15% of their daily intake. People in the highest income bracket consume only about 11% of their daily calories from sugar.

http://www.wisegeek.com/does-sugar-overconsumption-really-cause-cancer-and-contribute-to-heart-disease.htm
Posted by: AGelbert
« on: June 16, 2014, 01:45:51 pm »

Agelbert NOTE: interesting article on this new test WITH IMMINENT FDA approval that MAY avoid the cost (and risk from intestinal perforation) involved in a colonoscopy.  ;D I am not sure yet if that means EXAS is a buy but I'm watching it...  ;)

Cologuard Will Dominate Its Addressable Market


 May. 19, 2014 10:59 AM ET  |  54 comments |  About: EXACT Sciences Corporation (EXAS) 


Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.   
Summary

•A recent expert interview with a gastroenterologist indicated that Cologuard has significant market potential.

•Up to 30% of FIT patients would not be suitable for Cologuard, due to the need for colonoscopies roughly every 3-5 years anyway.

•Outside of those patients, Cologuard will own its addressable market and be rapidly adopted by physicians.

•Eventual penetration into the 70% range of this market is reasonable, and even at $300/test, Exact Sciences is undervalued.

http://seekingalpha.com/article/2225513-cologuard-will-dominate-its-addressable-market

Posted by: AGelbert
« on: April 30, 2014, 03:24:09 pm »

Water-based 'engine' propels tumor cells through tight spaces in the body

Johns Hopkins researchers have discovered a new mechanism that explains how cancer cells spread through extremely narrow three-dimensional spaces in the body by using a propulsion system based on water and charged particles.
    

The finding, reported in the April 24 issue of the journal Cell, uncovers a novel method the deadly cells use to migrate through a cancer patient's body. The discovery may lead to new treatments that help keep the disease in check. The work also points to the growing importance of studying how cells behave in three dimensions, not just atop flat two-dimensional lab dishes.

Based on such lab dish studies, cancer researchers had concluded that tumor cells require actin and other proteins to form arm-like extensions to "crawl" across the flat surfaces. This type of travel was believed to be the primary means of how cancer spreads within a patient, a process called metastasis. Based on this conclusion, researchers have been working on ways to disable actin and its molecular helpers, hoping this can keep cancer from spreading.

But in a study published in 2012, a Johns Hopkins team led by Konstantinos Konstantopoulos, chair of the Department of Chemical and Biomolecular Engineering, found that tumor cells could move through narrow spaces without using actin and its biochemical partners.

"That was a stunning discovery, not in line with the prevailing beliefs about how cells migrate," Konstantopoulos said. "So we wanted to figure out exactly how the tumor cells were able to move through these spaces without relying on actin."

He collaborated with Sean X. Sun, a Johns Hopkins associate professor of mechanical engineering with experience in math modeling and physics at microscopic levels.

"The mystery we needed to solve," Sun said, "was how the cells in these confined spaces could still move when you took away their usual 'engine,' the actin."



Kostantopoulos said Sun and Hongyuan Jiang, a postdoctoral fellow working in Sun's lab, "came up with a phenomenal mathematical model that provided insights into how the cells might use a different system to travel." Then Konstantopoulos and other team members, including Kimberly Stroka, a postdoctoral fellow in his own lab, used a microfluidic lab-on-a-chip and imaging techniques to conduct experiments establishing the new mechanism of migration proposed by Sun and Jiang's model. The tests utilized human and animal cancer cells. Stroka and Jiang were designated co-lead authors of the resulting journal article.

As reported in the article, the tumor cells' new "engine" turned out to be a combination of sodium-hydrogen ions, cell membrane proteins called aquaporins, and water.

                                                                 Aquaporin

The researchers found that within tight spaces, cancer cells create a flow of liquid that takes in water and ions at a cell's leading edge and pumps them out the trailing edge, propelling the cell forward. In the actin-dependent migration model, the cell is pushed forward by the biochemical equivalent of a boat engine. The water-based mechanism, the researchers said, more closely resembles the way a sailboat is thrust ahead by gusts of wind. The team called this mechanism the Osmotic Engine Model.

"This discovery is important because it reveals one reason why some diseases like cancer don't always respond to certain treatments," Konstantopoulos said. Sun added, "It's because these diseases have redundant mechanisms—more than one method—for migrating through the body."

Agelbert Note: This discovery is also important because it underlines the vital importance of maintaining a proper level of hydration in the human body. DEHYDRATION will slow immune system response but WON'T slow the cancer mets!  :o :P This is another good reason to stay properly hydrated.


 Explore further: Cancer cells don't take 'drunken' walks through the body

Journal reference:  Cell search and more info website

Provided by  Johns Hopkins University

graphics and video at link


http://medicalxpress.com/news/2014-04-water-based-propels-tumor-cells-tight.html

Posted by: AGelbert
« on: April 26, 2014, 02:06:57 pm »


What Happens When You Pee in the Pool? April 26, 2014   

By Dr. Mercola

One in five Americans admit they have peed in a pool, and among Olympic swimmers, the practice is so widespread that a former US National team member said nearly 100 percent of competitive swimmers pee in the pool… regularly.1

Swimming in a urine-contaminated pool is certainly not the most pleasant thought, but is it really so bad?

Olympic swimmer Michael Phelps doesn't think so, and famously said that "chlorine kills it [urine]," making peeing in the pool a non-issue. But it's not the urine itself that you need to worry about.

Urine is virtually sterile when it leaves your body, so it doesn't pose the risk of causing illness the way fecal matter in a pool does. In fact, urine is a valuable source of nutrients that is now being used as an effective and natural fertilizer.

So it's not the urine that is the problem… it's what happens when urine mixes with pool chemicals, including chlorine, that is catching researchers' attention.

Peeing in the Pool Creates a Chemical Warfare Agent  :o  :P

Highly toxic disinfection byproducts (DBPs) form from reactions between pool disinfectants and organic matter, including hair, skin, sweat, dirt and… urine. In a new study, researchers mixed uric acid from human urine with chlorine and found it creates two DBPs: cyanogen chloride (CNCl) and trichloramine (NCl3).2


The former, CNCI, is classified as a chemical warfare agent and is a known toxicant to your lungs, heart, and central nervous system. NCl3 is linked to lung damage.

As for how dangerous this is, practically speaking, the researchers found that, in a worst-case scenario, urine in a pool might lead to about 30 parts per billion (ppb) of cyanogen chloride, which is well below the 70 ppb used as the maximum cyanogen concentration allowed in drinking water, according to the World Health Organization (WHO).3 

Cyanogen chloride leads to coma, convulsions and death only at much higher levels (about 2,500 ppb),[size=12pt] an amount that would be difficult, and probably impossible, to generate in a typical swimming pool from urination alone.[/size]4 This doesn't mean that smaller doses are "safe," however, as DBPs have been linked to serious health problems at levels found in swimming pools.

According to the study researchers, since urinating in a pool introduces uric acid that will lead to the formation of a poison when it interacts with chlorine, it should be avoided:

" …uric acid chlorination may account for a large fraction of CNCl formation in swimming pools. Moreover, given that uric acid introduction to pools is attributable to urination, a voluntary action for most swimmers, these findings indicate important benefits to pool water and air chemistry that could result from improved hygiene habits on the part of swimmers."
Spending Just 40 Minutes in a Chlorinated Pool May Lead to DNA Damage
If you've ever wondered if the chlorine in a swimming pool poses a health risk, you'll find it unsettling to know that the DBPs created by chlorine reactions are far more dangerous. In fact, when researchers measured evidence of genotoxic (DNA damage that may lead to cancer) and respiratory effects on swimmers who swam in a chlorinated pool for just 40 minutes, they found:5
•Increased micronuclei in blood lymphocytes, which are associated with cancer risk
•Urine mutagenicity, a biomarker of exposure to genotoxic agents
•An increase in serum CC16, which suggests an increase in lung epithelium permeability


Adding chlorine to a swimming pool results in the formation of hundreds of DBPs because of the organic matter in the water. The researchers found that total concentrations of four DBPs (trihalomethanes (THMs)) were seven times higher in exhaled breath after swimming than they were before.  :P They noted:

"Our findings support potential genotoxic effects of exposure to DBPs from swimming pools. The positive health effects gained by swimming could be increased by reducing the potential health risks of pool water."

DBPs in Swimming Pools Are Linked to Cancer

It's known that trihalomethanes (THMs), one of the most common DBPs, are Cancer Group B carcinogens, meaning they've been shown to cause cancer in laboratory animals. They've also been linked to reproductive problems in both animals and humans, such as spontaneous abortion, stillbirths, and congenital malformations, even at lower levels.

It's not only swimming pools that are problematic, as DBPs also exist in chlorinated drinking water. Ingesting chlorinated water with levels of DBPs common in many industrialized countries has been linked to an increased risk of bladder cancer.6

However, when researchers also looked at exposure to DBPs through your skin and via inhalation (such as occurs while showering, bathing and swimming in pools), it was found to be an even greater risk than drinking water.7

Furthermore, people who frequent swimming pools have an increased risk of bladder cancer compared to those who do not,8 and DBPs have even been suggested as partially responsible for the increased risk of melanoma cancer among swimmers.9

According to one study published in the Journal of Environmental Sciences,10 the cancer risk of DBPs (in this case THMs) from various routes in descending order was:
1.Skin exposure while swimming
2.Gastrointestinal exposure from tap water intake
3.Skin exposure to tap water
4.Gastrointestinal exposure while swimming



The cancer risk from skin exposure while swimming comprised over 94 percent of the total cancer risk resulting from being exposed to THMs! The authors even went so far as to conclude that swimming in a chlorinated pool presents "an unacceptable cancer risk."


DBPs Pose Risks of Allergies, Asthma, and Other Health Problems

Most public pools are overloaded with chlorine, as the well-intentioned people who maintain public pools overly shock them with chlorine to make sure bacteria and other organisms get snuffed out quickly. But even the swimming pool in your backyard could be toxic if you treat it with chlorine – even if you know no one is using it to pee in.

Remember, any organic matter – including hair, skin, sweat, and dirt – can react with chlorine to create DBPs. So if you use chlorine, it's going to be virtually impossible to avoid some exposure. Many studies have pointed out the health risks associated with swimming in chlorinated water, and many of these are related to toxic DBPs:
•Swimming instructors are more than twice as likely to suffer frequently from sinusitis or sore throat, and more than three times as likely to have chronic colds, than pool workers with less DBP exposure, such as catering employees or receptionists.11
•Compared to the general population, pool workers with high levels of exposure were at a 40 percent greater risk for tightness of the chest and were over 700 percent more likely to suffer breathlessness while walking.12
•DBPs may cause weakening of your immune system, disruptions to your central nervous system, damaging effects to your cardiovascular system, unhealthy functioning of your renal system and harmful impacts to your respiratory system.

Should You Avoid Swimming Pools?  ???

The risk of DBP exposure from swimming pools is real, but it doesn't necessarily mean you have to give up swimming. Swimming in an ocean    ;D is an excellent alternative,  as is swimming in a lake or other natural body of water. You can also find a way to keep your pool clean from bacteria, algae, and other organisms without the use of dangerous chemicals, such as choosing a saltwater pool. 

One of the best solutions is NOT to chlorinate your pool and just use a maintenance "shock" treatment every five or six days, which will kill the algae buildup. The shock treatment volatilizes in about 24-48 hours and gives you a several-day window in which you can safely use your pool. You can also reduce the amount of organic material you bring into the pool, and thereby the amount of DBPs created, by showering prior to entering and teaching your children    not to urinate in the water. You can also use ozone, which also oxidatively destroys the pool pathogens and lowers the need for chlorine.

This will be difficult if you're visiting a public swimming pool or waterpark, however. Surveys show that 35 percent of Americans say they do not shower prior to entering a pool. Finally, because DBPs exist in all chlorinated water, I recommend installing water filters that remove chlorine for both your shower/bath and your kitchen tap.

http://articles.mercola.com/sites/articles/archive/2014/04/26/urine-chlorinated-pool.aspx
Posted by: AGelbert
« on: April 06, 2014, 01:19:57 am »

Posted by: AGelbert
« on: April 02, 2014, 04:07:07 pm »

Posted by: AGelbert
« on: March 03, 2014, 01:18:01 am »

I'm sorry to hear about your niece. So young!  :( And yes, it seems cancer cells absolutely love sugar. I stopped putting sugar in my coffee seven years ago. My health has improved because of it.  8)
I'm convinced sugar is far more dangerous to human health and a bigger culprit in high blood pressure than salt even though salt in excess can be damaging.

By the way, my SPEP/UPEP came out normal. So far, so good.
Posted by: AGelbert
« on: March 02, 2014, 05:40:26 pm »

http://www.youtube.com/watch?v=RTGXuzlfdp4&feature=player_embedded

Quote
By Dr. Mercola


Cancer is one of the leading causes of death. What if there was a safe, natural herb that could work for nearly every type of cancer? 


According to Dr. William LaValley, who focuses most of his clinical work on the treatment of cancer, curcumin—a derivative of turmeric, and the pigment that gives the curry spice turmeric its yellow-orange color—may fit the bill. It's a natural compound that has been extensively researched, and has been found to have numerous health applications.

Like me, Dr. LaValley was trained in general medicine, but he's devoted a considerable amount of time to understanding the biochemical pathways that can support health nutritionally.

In 1982, he participated in an exchange program to the People's Republic of China, where he got first-hand experience with the ancient practices of traditional Chinese medicine and acupuncture.


"One of the important messages that I learned there was that natural products, natural molecules, from plants and animals that are already available in nature, have been used by the Chinese for at least hundreds, probably thousands of years. That deeply changed my perspective in the world of medicine," he says.


"I came back to medical school, and thereafter, looked at how I could integrate the perspective of conventional pharmaceutical administration as well as natural extract, natural product administration."

Curcumin Has Potent Anti-Cancer Activity



In 2005, he took a 75 percent sabbatical from clinical practice to immerse himself in the science of molecular biology, specifically the molecular biology of cancer. He also devoted approximately 9,000-9,500 hours building a relational database from the PubMed literature about the molecular biology of cancer.

One important lesson he learned through that venture is that the understanding of molecular biology can be applied across a range of diseases and symptoms described in the scientific literature. That knowledge can be applied by searching PubMed and other related databases, looking at the relevant molecular pathways involved.


"In learning the molecular biology of cancer pathways, and in learning that what the evidence actually shows for the effect of natural product extracts on various relevant molecular targets in various cancers,

We see that there's actually quite a large amount of evidence that supports using various molecules, natural products, and pharmaceuticals that are already approved and that have been around for a long time to affect anti-cancer activity along that pathway at that target. That's called molecularly targeted anti-cancer treatment, and it's widely practiced in oncology today.


What's not widely practiced is the use of the natural products for the molecularly targeted anti-cancer activity. I provide that for my patients because the evidence base suggests and supports the use of these treatment recommendations."

Curcumin—A 'Universal' Cancer Treatment?


Interestingly, curcumin appears to be universally useful for just about every type of cancer, which is really odd since cancer consists of a wide variety of different molecular pathologies. You wouldn't necessarily suspect that there would be one herb that would work for most of them. Dr. LaValley explains how he came to this conclusion:


"I went back to the literature and looked at how I can support the decision-making process and the recommendations that I'm making for treatment from the scientific literature, including literature that goes from the treatment of humans with oral products like pharmaceuticals or natural products.


This is where I learned about this molecule called curcumin, all the way down to its use in animals and then its use in test tubes or petri dish... One of the amazing things about curcumin is that this molecule has some profound anti-inflammatory activity and has activity in many molecular targets.


There are molecules that are in the cells, and those molecules interact with each other along certain pathways or tracks. The traffic of that interaction, the signals that are transferred in that trafficking of information in the molecules, presents many different targets or molecular-specific complexes."

As explained by Dr. LaValley, whether the curcumin molecule causes an increase in traffic or activity of a particular molecular target, or a decrease/inhibition of activity, studies repeatedly show that the end result is a potent anti-cancer activity. Furthermore, curcumin does not adversely affect healthy cells, suggesting it selectively targets cancer cells. Research has also shown that it works synergistically with certain chemotherapy drugs, enhancing the elimination of cancer cells.

Curcumin Destroys Cancer in Multiple Ways


Curcumin has the most evidence-based literature1 supporting its use against cancer of any nutrient, including vitamin D, which also has a robust base. Interestingly, this also includes the metabolite of curcumin and its derivatives, which are also anti-cancerous.

Curcumin has the ability to modulate genetic activity and expression—both by destroying cancer cells and by promoting healthy cell function. It also promotes anti-angiogenesis, meaning it helps prevent the development of additional blood supply necessary for cancer cell growth. As for its effect on molecular pathways, curcumin can affect more than 100 of them, once it gets into the cell. More specifically, curcumin has been found to:

Inhibit the proliferation of tumor cells  Decrease inflammation 
Inhibit the transformation of cells from normal to tumor  Inhibit the synthesis of a protein thought to be instrumental in tumor formation 
Help your body destroy mutated cancer cells so they cannot spread throughout your body  Help prevent the development of additional blood supply necessary for cancer cell growth (angiogenesis) 

Why Whole Turmeric Is Ineffective


Unfortunately, while there's some curcumin in whole turmeric, there's not enough in the regular spice to achieve clinically relevant results. The turmeric root itself contains only about three percent curcumin concentration. Another major limitation of curcumin as a therapeutic agent is that it is poorly absorbed. When taken in its raw form, you're only absorbing about one percent of the available curcumin.


"The natural product industry has developed a standard of a 95-percent concentration of curcumin," Dr. LaValleyexplains. "Initially, years ago, that was what we had available for patients. Even at that, taking a 95-percent concentration orally in a capsule, only one percent of that could be absorbed. In order to get amounts of curcumin in the bloodstream that are reasonable to have therapeutic effect, people had to take large amounts of curcumin...


In searching the literature, I found that a way to change that, to dramatically increase the bioavailability, is actually a very simple process of bringing water to a boil, putting those capsules or some dry powder (I use it by the teaspoon), and boiling it for 10 to 12 minutes. That increases the amount of curcumin dissolved in water from that one-percent amount up to 12 percent or so. That amount is a vast number of curcumin molecules that are now in a bioavailable or absorbable form."

However, while this is certainly doable, it's really inconvenient, and great care must be taken to prevent staining your clothes and kitchen surfaces. It's a significant enough problem to have been dubbed "yellow kitchen syndrome," as it's virtually impossible to get the stains out. Turmeric is in fact an excellent dyeing agent for fabrics, rendering them a yellow-orange color.

Convenience and efficiency has driven many of the changes in the forms of curcumin in later years. Because it's a fat-loving or lipophilic molecule, many newer preparations now include some sort of oil or fat, which improves its absorbability and bioavailability. Such preparations typically have seven to eight times higher absorption than the raw, unprocessed 95-percent-concentration of dry powder. There are also newer sustained release preparations, which Dr. LaValley prefers and recommends.

The Connection Between Cancer and Insulin Resistance


If you are overweight, or have high blood pressure, high cholesterol, and/or diabetes, then in all likelihood insulin and leptin resistance is a factor. Insulin and leptin resistance is also a very common factor among cancer patients. From my perspective, a ketogenic diet (with or without intermittent fasting) would be a prudent treatment strategy to resolve that underlying problem. Once you've normalized your insulin and leptin, you don't necessarily need to maintain a ketogenic diet, if you find it too restrictive.


"I agree with you that a ketogenic diet is really appropriate in many cases, probably the significant majority of cases," Dr. LaValley says. "It's been known for probably 80 years or longer that solid tumors, and some of the blood cancers, are sugar-loving. Another term is that they are addicted to sugar.


I use [a] PET scan to demonstrate to patients that here is objective proof that the tumors you have in your body are sugar-avid. They're taking up sugar at a rate much higher than the other regular healthy cells. I want to drive home that message, so that they are motivated to alter their diet to have a low, low carb intake, causing their body to generate additional nutrient supply molecules called ketones...


What that means is that we're trying to provide an anti-cancer antagonistic pressure on the cancer cells by reducing the amount of sugar that's readily available for uptake by reducing the easily available sugar in the diet and compensating for the nutrient reduction and sugar [reduction] by increasing healthy fats."

Cutting Down on Protein May Be Particularly Useful for Cancer Patients


It would also be prudent to assess your protein intake. Many Americans eat far more protein than required for optimal health. The reason for this is because your body can actually use excess protein (you do need some) to stimulate carbohydrate production. Excess protein also stimulates the mammalian target of rapamycin (mTOR) pathways, which are useful for building muscles but can be detrimental when treating cancer, as mTOR is a pathway that increases cellular proliferation. (Interestingly, the pharmaceutical drug Metformin, which has anti-cancer activity, also inhibits mTOR, and it turns out that curcumin has a very similar effect.)

The formula I recommend for assessing how much protein you might need in your diet is from Dr. Rosedale, which calls for one gram of high-quality protein per kilogram of lean body mass, or about half a gram per pound of lean body mass.

As an example, if your body fat mass is 20 percent, your lean mass is 80 percent of your total body weight. So, if your total weight is 200 pounds; you would then divide 160 by 2.2 to convert pounds to kilograms and come up with 72.7 grams of protein. If you are doing vigorous exercises or are pregnant, you can add up to another 25 percent or another 18 grams in this illustration to increase your total to 90 grams per day.

More Information


Dr. LaValley is available for consultation on a wide variety of health challenges, including cancer, and he's licensed to practice medicine in the US and Canada. His medical clinic is located in Chester, Nova Scotia, where he sees patients. Americans can fly there either through Chicago or Newark. His office number is 902-275-4555. He also spends time in Austin, Texas, where he conducts research. When there, he's available to consult for other physicians and their patients.


"For instance, if a patient has pancreatic cancer and the physician wants to implement one of the protocols that I provide, I will do a consultation with that physician's patient and then make recommendations to that physician for implementation,"  he explains. "In that way, patients are able to get it locally without having to travel to Nova Scotia...


It's a challenge right now because there's so much information that's not readily known by so many physicians that they become afraid. I think one of the biggest issues, certainly in US and Canada, is that when a physician wants to administer one of these natural products, or several of them, as well as some of the off-label pharmaceuticals for their anti-cancer usage, they are afraid of recriminations or disciplinary actions.


That is, I think, very unfortunate, because the evidence base does exist for it, and it's consistent with the way that other types of conventional medicine or practice using off-label pharmaceuticals as well. I think that the most important movement that needs to occur is for the patients to recognize their own value in the decision-making process and demand that they have access to these therapeutic choices because they're available, they're supported in the evidence base, and they have the right to ask for them rather than to just accept whatever the physician is otherwise offering in the conventional realm."

http://articles.mercola.com/sites/articles/archive/2014/03/02/curcumin-benefits.aspx

Agelbert NOTE: When my brother in law was dying of colon cancer with mets to the liver last year, he began to take Curcumin massively but it was too late. Curcumin is a strong blood thinner and he began to bleed profusely. This hastened his death.

So Curcumin, like may other natural products out there, is useful in preventing cancer and any condition that a blood clot could cause like an embolism or heart attack. The KEY is prevention. Once the cancer is there, something like concentrated Hemp Oil is in order. Blood thinners are bad news when you are bleeding from cancer produced tumors or sores.

I am not a doctor; I just read a lot and like to share my experience. Use discretion.
Posted by: AGelbert
« on: February 18, 2014, 02:50:00 pm »

Image of the Day: Apoptotic Cell

As HeLa cells die, they produce characteristic spikes and rounded blebs from their surfaces.

By The Scientist Staff | February 18, 2014

(image at link)
http://www.the-scientist.com//?articles.view/articleNo/39188/title/Image-of-the-Day--Apoptotic-Cell/

Apoptosis is normal, programmed, healthy system cell death. No apoptosis leads to inflammation and cancer.
Posted by: AGelbert
« on: November 10, 2013, 10:51:50 pm »

http://www.youtube.com/watch?v=o4VxLmH2pwc&feature=player_embedded
Yes, there is another topic thread with Rick Simpson's Hemp Oil. But this video is mostly about his discovery of Hemp Oil as a cancer cure. Enjoy. ;D
Posted by: AGelbert
« on: November 02, 2013, 04:56:58 pm »

One of Cancer's BEST FRIENDS: HIGH BLOOD SUGAR




My fasting serum glucose is at 94. What's yours? Avoid SWEET MISERY; avoid refined sugar and eating large portions of white, refined simple carbs because they do a number on your blood sugar and do little to satisfy your appetite.

More and more, modern medicine is realizing that cholesterol, fats and other lipids as well as salt are NOT the killers they were once thought to be. It now appears that those begin to deteriorate your health as a consequence of high blood sugar.



WHY? Because your body metabolizes all the above quite well UNTIL you have problems with inflammation. Then the cleansing activity loses efficiency.

What's the killer sugar connection?

1. When there is more sugar in your blood stream than your cells need, the receptors "get used to FEAST" and make it harder to bind to them to make energy. Really badly blocked receptors is what diabetes is all about. When low blood sugar occurs (FAMINE), your body, used to FEAST, cannot get all the energy it needs from blocked receptors and you get lethargic in addition to inefficent handling of cholesterol, fats and immune function.

2.   The extra sugar in your system, because sugar molecules have a jagged shape, cut capillary walls and start the inflammation vicious cycle (mast cells on the vessel walls release histones from sugar molecules bound to hemoglobin - red blood cells - banging against them). People who are chronically dehydrated because they hit the jar too much excacerbate the sugar molecule damage to capillary vessel walls giving all the above difficulties a boost.



Normal arterial blood flow




continuous capillary tight-junction -intercellular cleft

Quote
Blood sugar actually coats red blood cells (hemoglobin), causing them to become stiff. These "sticky cells" interfere with blood circulation, causing cholesterol to build up on the inside of your blood vessels. It can take months to years for the damage to your body to appear. The fragile blood vessels in your eyes, kidneys and feet are most susceptible, so problems are usually noticed first in those areas.
http://www.mayoclinic.com/health/high-blood-sugar/MY01701


3. Cancer cells ARE NOT concerned with keeping things homeostatic. They have one main mission in life: RAPID GROWTH. And to GROW FAST, you need LOTS OF ENERGY! That is why cancer LOVES SUGAR.





So give up the donut love and daily boozing as well as large portions of blood sugar boosting simple carbohydrate foods like pretzels and beer. That is truly an unhealthy combination because (among several others pushed by our ignorant, hyper consumerist, instant gratification society as cultural icons - apple pie anyone?  :P ) you are dehydrating yourself while simultaneously jacking up your blood sugar. Too much refined white rice, potatoes, etc. are bad for you. Boozing every day is bad for you because it leads to a chronic dehydrated circulatory system.


So why do we like all that stuff so much if it is "bad" for us?  ??? Because we are energy seekers and our taste buds are designed to zero in on anything that has high sugar (or high in simple carbs that can be quickly converted to sugar). We were designed to operate in an environment where we could go long stretches ( a few days) without food as long as we could get water.

Having FEAST conditions ALL THE TIME creates a feedback mechanism from our body to radically reduce our ability to process sugars because the body ASSUMES a "new normal" of no longer having to be as efficient at sucking up all the available energy around.

Our biochemistry, being homeostatic, tries its best to balance this excess of energy but ultimately fails from too much inflammation. The immune system gets more and more compromised and along comes one of those MUTATIONS the evolutionist true believers love so much to 'EVOLVE' us into a new and improved bunch of cancer tumors.  ???

Yeah, I know people don't call that evolution because the mutations that cause cancer are NEGATIVE mutations, not "evolutionary advantages" (Unless you are a cancer!  ;D LOL!). But unfortunately for the evolutionist true believers, 98% of all mutations in nature, as observed by modern scientific inquiry over the last 50 years (at least) with detailed analysis, are DNA destructive mutations, not new super powers from natural selection.  ;)

So, if you want to believe in evolution, have a ball. But don't plan on "evolving" out of destroying your immune system with high blood sugar any time soon.   

My Fasting Serum Glucose is 94. What's yours?

More on why high blood sugar is bad for you:

New Evidence Of How High Glucose Damages Blood Vessels Could Lead To New Treatments
http://www.sciencedaily.com/releases/2009/05/090511140951.htm
Posted by: AGelbert
« on: October 30, 2013, 08:53:20 pm »

Flavonoids In Celery And Artichokes Kill Cancer Cells 





Brett Smith for redOrbit.com – Your Universe Online

Vegetables like celery and artichokes have long been thought to convey numerous health benefits, and a new study from scientists at University of Illinois at Urbana-Champaign revealed that these foods have two chemical components, apigenin and luteolin, known as flavonoids that are capable of killing off cancer cells.

“Apigenin alone induced cell death in two aggressive human pancreatic cancer cell lines. But we received the best results when we pre-treated cancer cells with apigenin for 24 hours, then applied the chemotherapeutic drug gemcitabine for 36 hours,” said study author Elvira de Mejia, a U of I food chemistry and toxicology professor.

The researchers found that using the two flavonoids as a pretreatment was more effective than applying them together with the chemotherapeutic drug simultaneously. In fact, applying both the drug and the flavonoids at the same time resulted in a highly undesirable effect.

“Even though the topic is still controversial, our study indicated that taking antioxidant supplements on the same day as chemotherapeutic drugs may negate the effect of those drugs,”
said Jodee Johnson, a U of I researcher who worked on the study as a doctoral student in de Mejia’s lab.

“That happens because flavonoids can act as antioxidants,” she added. “One of the ways that chemotherapeutic drugs kill cells is based on their pro-oxidant activity, meaning that flavonoids and chemotherapeutic drugs may compete with each other when they’re introduced at the same time.”

In the study, which was published in the journal Molecular Nutrition and Food Research, the Illinois researchers found that apigenin blocked an enzyme called glycogen synthase kinase-3β (GSK-3β), which led to a drop in the production of anti-apoptotic genes in the pancreatic cancer cells. These genes cause a cancer cell to self-destruct because its DNA has been damaged.

In one cell line, the percentage of self-destructing cancer cells went from 8.4 percent in cells that had not been dosed with apigenin to almost 44 percent in cells that had been administered a 50-micromolar dose of the flavonoid. Chemotherapy drugs had not been used on either group of cells.

The researchers also found that apigenin modified gene expression.
“Certain genes associated with pro-inflammatory cytokines were highly upregulated,” de Mejia said.

While pancreatic cancer patients would probably not be able to eat enough celery or artichokes to boost flavonoids in the blood to an effective level, drugs or supplements could be used to achieve the desired concentrations, according to de Mejia.

The Illinois food scientist added that everyone should consider adding foods high in flavonoids to their regular diet.

“If you eat a lot of fruits and vegetables throughout your life, you’ll have chronic exposure to these bioactive flavonoids, which would certainly help to reduce the risk of cancer,” she noted. 


Researchers have been looking into the anti-cancer properties of flavonoids for years. A study published in 2008 by UCLA researchers found that smokers who ate foods rich in certain flavonoids, including strawberries, brussel sprouts and apples, may reduce their lung cancer risk.

Source: Brett Smith for redOrbit.com - Your Universe Online

http://www.redorbit.com/news/health/1112925354/flavonoids-in-celery-artichokes-kill-cancer-cells-081613/

Posted by: AGelbert
« on: October 24, 2013, 10:56:07 pm »

Jack Andraka invents effective and cheap test for Pancreatic Cancer EARLY (as in 100% curable) diagnosis!



A Teen Wrote 200 Letters To Get Lab Space. All But One Said No. Now, Cancer Should Be Very Worried.


I'm equal parts inspired by and angry for this kid. Despite having this incredible idea, he's turned away and discouraged by "experts." When one lab gives him a chance, he shows that kids aren't just the future, but also the present.


Rajiv Narayan

UPWORTHY Video Here
 
Posted by: AGelbert
« on: October 18, 2013, 08:35:21 pm »

Posted by: AGelbert
« on: October 14, 2013, 10:13:39 pm »

Cancer’s Favorite Ingredient
Megan, selected from Experience Life
October 13, 2013
4:30 pm


From Experience Life

The average American eats 70 grams of fructose per day — a number triple the recommended daily limit.

A study published last summer in Cancer Research shows that fructose is even more of a nutritional villain than previously suspected. More than any other kind of sugar, it appears to trigger cancer cells to divide and proliferate.

Researchers at the University of California–Los Angeles extracted pancreatic tumor cells from patients and grew the cells in petri dishes. They added glucose (another simple sugar long known to fuel the growth of cancer cells) to one dish and fructose to the other. The cancer cells used both glucose and fructose as fuel, but the fructose also activated the cellular pathway that drives cell division while triggering cellular activities that helped cancer cells rapidly metabolize both fructose and glucose.[/b][/size]

The main source of fructose in the North American diet is high-fructose corn syrup and other refined sweeteners, such as sucrose, dextrose and maltose. U.S. consumption of high-fructose corn syrup alone shot up 1,000 percent between 1970 and 1990.  >:(

Today, the average American eats 70 grams of fructose per day — a number triple the recommended daily limit.

7 Tricks to Tame Your Sweet Tooth

The best way to limit fructose intake is to greatly reduce or eliminate processed foods and sweetened beverages from your diet. But you can further limit your total fructose intake by choosing fruits — like berries and stone fruits — that have lower fructose concentrations, and going easy on fruit juices and dried fruits, which deliver a lot of fructose per serving. Osteopathic physician and New York Times best-selling author Joseph Mercola, MD, suggests no more than 20 grams of fructose per day, with no more than 15 grams coming from fruit.

Next: Which fruit has the most fructose?


The Fructose in Fruit

Fruits are good sources of nutrients and fiber, but some contain a significant payload of fructose, too. Here’s a low-to-high listing of some commonly eaten fruits (grams of fructose in bold):

Low
Peaches — 1 cup, 154 g — 2.36 g
Clementines — 2 fruits, 148 g — 2.42 g
Raspberries — 1 cup, 123 g — 2.89 g

Medium
Pineapples — 1 cup, 165 g — 3.50 g
Grapefruit — 1 cup, 230 g — 4.07 g

High
Bananas — 1 cup, 150 g — 7.28 g
Apples — 1 cup, 125 g — 7.37 g
Mangoes — 1 cup, 165 g — 7.72 g   
Pears — 1 fruit, 148 g — 9.22 g


http://www.care2.com/greenliving/cancers-favorite-ingredient.html

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October 10, 2019, 04:53:21 pm