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Author Topic: Psoriasis and other Autoimmune Disorders  (Read 294 times)

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AGelbert

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Psoriasis and other Autoimmune Disorders
« on: September 09, 2015, 03:01:57 pm »
Vitae Pharmaceuticals Announces Positive Top-Line Results From Initial Phase 1 Study of First-in-Class RORyt Inhibitor VTP-43742 in Autoimmune Disorders

• Single ascending doses of VTP-43742 safe and generally well-tolerated, demonstrated once-daily pharmacokinetics

• Robust ex vivo biomarker response, suppressing pro-inflammatory IL-17A by more than 90 percent

FORT WASHINGTON, Pa., Sept. 8, 2015 (GLOBE NEWSWIRE) -- Vitae Pharmaceuticals, Inc. (NASDAQ:VTAE), a clinical-stage biotechnology company, today announced positive top-line results from its Phase 1 single ascending dose clinical study of VTP-43742 in autoimmune disorders. VTP-43742 is Vitae's first-in-class, wholly owned RORγt inhibitor being developed for the treatment of a range of autoimmune disorders, potentially including psoriasis, psoriatic arthritis, rheumatoid arthritis, multiple sclerosis and irritable bowel disease (IBD), as well as numerous orphan diseases.


http://ir.vitaepharma.com/phoenix.zhtml?c=219654&p=irol-newsArticle&ID=2086185

VTAE stock jumps over 70%! :o

Rob not the poor, because he is poor: neither oppress the afflicted in the gate:
For the Lord will plead their cause, and spoil the soul of those that spoiled them. Pr. 22:22-23

AGelbert

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Itches: Causes and Consequences
« Reply #1 on: May 11, 2019, 02:43:30 pm »

Why Do Itches Seem to Get Worse When You Scratch Them?

It’s a vicious cycle. You’ve got this itch that just has to be scratched. Then you scratch so hard that it hurts. That’s where the brain comes in, releasing serotonin to calm the pain you’ve created. The unfortunate side effect of all that, scientists have discovered, is that the release of serotonin also activates brain cells called GRPR neurons, which trigger a renewed round of that uncontrollable urge to itch. :( Researchers at the Washington University School of Medicine in St Louis came to this conclusion in 2014 while studying genetically-modified mice that did not produce serotonin.

Itches, scratches, and serotonin:

🕯️ Normal mice injected with a chemical will scratch like crazy. The researchers found that without the serotonin response, the mice had no urge to scratch, thus proving serotonin’s role in the process. 👀

🕯️ Could blocking serotonin in humans stop the itch? Maybe, but then they’d have no natural way to control pain. However, there may be a way to stop serotonin from activating the nerve cells in the spinal cord that instigate itch. 🤔

🕯️ The researchers 👨‍🔬 did identify the nerve receptor known as 5-HT1A as the key to unleashing those itch-specific GRPR neurons in the spinal cord. Their research appeared in the scientific journal Neuron.

https://www.wisegeek.com/why-do-itches-seem-to-get-worse-when-you-scratch-them.htm
Rob not the poor, because he is poor: neither oppress the afflicted in the gate:
For the Lord will plead their cause, and spoil the soul of those that spoiled them. Pr. 22:22-23

 

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