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AGelbert

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Cancer
« on: October 14, 2013, 10:13:39 pm »
Cancer’s Favorite Ingredient
Megan, selected from Experience Life
October 13, 2013
4:30 pm


From Experience Life

The average American eats 70 grams of fructose per day — a number triple the recommended daily limit.

A study published last summer in Cancer Research shows that fructose is even more of a nutritional villain than previously suspected. More than any other kind of sugar, it appears to trigger cancer cells to divide and proliferate.

Researchers at the University of California–Los Angeles extracted pancreatic tumor cells from patients and grew the cells in petri dishes. They added glucose (another simple sugar long known to fuel the growth of cancer cells) to one dish and fructose to the other. The cancer cells used both glucose and fructose as fuel, but the fructose also activated the cellular pathway that drives cell division while triggering cellular activities that helped cancer cells rapidly metabolize both fructose and glucose.[/b][/size]

The main source of fructose in the North American diet is high-fructose corn syrup and other refined sweeteners, such as sucrose, dextrose and maltose. U.S. consumption of high-fructose corn syrup alone shot up 1,000 percent between 1970 and 1990.  >:(

Today, the average American eats 70 grams of fructose per day — a number triple the recommended daily limit.

7 Tricks to Tame Your Sweet Tooth

The best way to limit fructose intake is to greatly reduce or eliminate processed foods and sweetened beverages from your diet. But you can further limit your total fructose intake by choosing fruits — like berries and stone fruits — that have lower fructose concentrations, and going easy on fruit juices and dried fruits, which deliver a lot of fructose per serving. Osteopathic physician and New York Times best-selling author Joseph Mercola, MD, suggests no more than 20 grams of fructose per day, with no more than 15 grams coming from fruit.

Next: Which fruit has the most fructose?


The Fructose in Fruit

Fruits are good sources of nutrients and fiber, but some contain a significant payload of fructose, too. Here’s a low-to-high listing of some commonly eaten fruits (grams of fructose in bold):

Low
Peaches — 1 cup, 154 g — 2.36 g
Clementines — 2 fruits, 148 g — 2.42 g
Raspberries — 1 cup, 123 g — 2.89 g

Medium
Pineapples — 1 cup, 165 g — 3.50 g
Grapefruit — 1 cup, 230 g — 4.07 g

High
Bananas — 1 cup, 150 g — 7.28 g
Apples — 1 cup, 125 g — 7.37 g
Mangoes — 1 cup, 165 g — 7.72 g   
Pears — 1 fruit, 148 g — 9.22 g


http://www.care2.com/greenliving/cancers-favorite-ingredient.html
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AGelbert

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« Last Edit: October 18, 2013, 08:57:55 pm by AGelbert »
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AGelbert

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Jack Andraka invents effective and cheap test for Pancreatic Cancer EARLY (as in 100% curable) diagnosis!



A Teen Wrote 200 Letters To Get Lab Space. All But One Said No. Now, Cancer Should Be Very Worried.


I'm equal parts inspired by and angry for this kid. Despite having this incredible idea, he's turned away and discouraged by "experts." When one lab gives him a chance, he shows that kids aren't just the future, but also the present.


Rajiv Narayan

UPWORTHY Video Here
 
« Last Edit: October 24, 2013, 11:04:55 pm by AGelbert »
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AGelbert

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Flavonoids In Celery And Artichokes Kill Cancer Cells 





Brett Smith for redOrbit.com – Your Universe Online

Vegetables like celery and artichokes have long been thought to convey numerous health benefits, and a new study from scientists at University of Illinois at Urbana-Champaign revealed that these foods have two chemical components, apigenin and luteolin, known as flavonoids that are capable of killing off cancer cells.

“Apigenin alone induced cell death in two aggressive human pancreatic cancer cell lines. But we received the best results when we pre-treated cancer cells with apigenin for 24 hours, then applied the chemotherapeutic drug gemcitabine for 36 hours,” said study author Elvira de Mejia, a U of I food chemistry and toxicology professor.

The researchers found that using the two flavonoids as a pretreatment was more effective than applying them together with the chemotherapeutic drug simultaneously. In fact, applying both the drug and the flavonoids at the same time resulted in a highly undesirable effect.

“Even though the topic is still controversial, our study indicated that taking antioxidant supplements on the same day as chemotherapeutic drugs may negate the effect of those drugs,”
said Jodee Johnson, a U of I researcher who worked on the study as a doctoral student in de Mejia’s lab.

“That happens because flavonoids can act as antioxidants,” she added. “One of the ways that chemotherapeutic drugs kill cells is based on their pro-oxidant activity, meaning that flavonoids and chemotherapeutic drugs may compete with each other when they’re introduced at the same time.”

In the study, which was published in the journal Molecular Nutrition and Food Research, the Illinois researchers found that apigenin blocked an enzyme called glycogen synthase kinase-3β (GSK-3β), which led to a drop in the production of anti-apoptotic genes in the pancreatic cancer cells. These genes cause a cancer cell to self-destruct because its DNA has been damaged.

In one cell line, the percentage of self-destructing cancer cells went from 8.4 percent in cells that had not been dosed with apigenin to almost 44 percent in cells that had been administered a 50-micromolar dose of the flavonoid. Chemotherapy drugs had not been used on either group of cells.

The researchers also found that apigenin modified gene expression.
“Certain genes associated with pro-inflammatory cytokines were highly upregulated,” de Mejia said.

While pancreatic cancer patients would probably not be able to eat enough celery or artichokes to boost flavonoids in the blood to an effective level, drugs or supplements could be used to achieve the desired concentrations, according to de Mejia.

The Illinois food scientist added that everyone should consider adding foods high in flavonoids to their regular diet.

“If you eat a lot of fruits and vegetables throughout your life, you’ll have chronic exposure to these bioactive flavonoids, which would certainly help to reduce the risk of cancer,” she noted. 


Researchers have been looking into the anti-cancer properties of flavonoids for years. A study published in 2008 by UCLA researchers found that smokers who ate foods rich in certain flavonoids, including strawberries, brussel sprouts and apples, may reduce their lung cancer risk.

Source: Brett Smith for redOrbit.com - Your Universe Online

http://www.redorbit.com/news/health/1112925354/flavonoids-in-celery-artichokes-kill-cancer-cells-081613/

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AGelbert

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One of Cancer's BEST FRIENDS: HIGH BLOOD SUGAR
« Reply #4 on: November 02, 2013, 04:56:58 pm »
One of Cancer's BEST FRIENDS: HIGH BLOOD SUGAR




My fasting serum glucose is at 94. What's yours? Avoid SWEET MISERY; avoid refined sugar and eating large portions of white, refined simple carbs because they do a number on your blood sugar and do little to satisfy your appetite.

More and more, modern medicine is realizing that cholesterol, fats and other lipids as well as salt are NOT the killers they were once thought to be. It now appears that those begin to deteriorate your health as a consequence of high blood sugar.



WHY? Because your body metabolizes all the above quite well UNTIL you have problems with inflammation. Then the cleansing activity loses efficiency.

What's the killer sugar connection?

1. When there is more sugar in your blood stream than your cells need, the receptors "get used to FEAST" and make it harder to bind to them to make energy. Really badly blocked receptors is what diabetes is all about. When low blood sugar occurs (FAMINE), your body, used to FEAST, cannot get all the energy it needs from blocked receptors and you get lethargic in addition to inefficent handling of cholesterol, fats and immune function.

2.   The extra sugar in your system, because sugar molecules have a jagged shape, cut capillary walls and start the inflammation vicious cycle (mast cells on the vessel walls release histones from sugar molecules bound to hemoglobin - red blood cells - banging against them). People who are chronically dehydrated because they hit the jar too much excacerbate the sugar molecule damage to capillary vessel walls giving all the above difficulties a boost.



Normal arterial blood flow




continuous capillary tight-junction -intercellular cleft

Quote
Blood sugar actually coats red blood cells (hemoglobin), causing them to become stiff. These "sticky cells" interfere with blood circulation, causing cholesterol to build up on the inside of your blood vessels. It can take months to years for the damage to your body to appear. The fragile blood vessels in your eyes, kidneys and feet are most susceptible, so problems are usually noticed first in those areas.
http://www.mayoclinic.com/health/high-blood-sugar/MY01701


3. Cancer cells ARE NOT concerned with keeping things homeostatic. They have one main mission in life: RAPID GROWTH. And to GROW FAST, you need LOTS OF ENERGY! That is why cancer LOVES SUGAR.





So give up the donut love and daily boozing as well as large portions of blood sugar boosting simple carbohydrate foods like pretzels and beer. That is truly an unhealthy combination because (among several others pushed by our ignorant, hyper consumerist, instant gratification society as cultural icons - apple pie anyone?  :P ) you are dehydrating yourself while simultaneously jacking up your blood sugar. Too much refined white rice, potatoes, etc. are bad for you. Boozing every day is bad for you because it leads to a chronic dehydrated circulatory system.


So why do we like all that stuff so much if it is "bad" for us?  ??? Because we are energy seekers and our taste buds are designed to zero in on anything that has high sugar (or high in simple carbs that can be quickly converted to sugar). We were designed to operate in an environment where we could go long stretches ( a few days) without food as long as we could get water.

Having FEAST conditions ALL THE TIME creates a feedback mechanism from our body to radically reduce our ability to process sugars because the body ASSUMES a "new normal" of no longer having to be as efficient at sucking up all the available energy around.

Our biochemistry, being homeostatic, tries its best to balance this excess of energy but ultimately fails from too much inflammation. The immune system gets more and more compromised and along comes one of those MUTATIONS the evolutionist true believers love so much to 'EVOLVE' us into a new and improved bunch of cancer tumors.  ???

Yeah, I know people don't call that evolution because the mutations that cause cancer are NEGATIVE mutations, not "evolutionary advantages" (Unless you are a cancer!  ;D LOL!). But unfortunately for the evolutionist true believers, 98% of all mutations in nature, as observed by modern scientific inquiry over the last 50 years (at least) with detailed analysis, are DNA destructive mutations, not new super powers from natural selection.  ;)

So, if you want to believe in evolution, have a ball. But don't plan on "evolving" out of destroying your immune system with high blood sugar any time soon.   

My Fasting Serum Glucose is 94. What's yours?

More on why high blood sugar is bad for you:

New Evidence Of How High Glucose Damages Blood Vessels Could Lead To New Treatments
http://www.sciencedaily.com/releases/2009/05/090511140951.htm
« Last Edit: November 02, 2013, 05:54:29 pm by AGelbert »
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AGelbert

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Does Hemp Oil Cure Some Types of Cancer?
« Reply #5 on: November 10, 2013, 10:51:50 pm »
http://www.youtube.com/watch?v=o4VxLmH2pwc&feature=player_embedded
Yes, there is another topic thread with Rick Simpson's Hemp Oil. But this video is mostly about his discovery of Hemp Oil as a cancer cure. Enjoy. ;D
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AGelbert

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Image of the Day: Apoptotic Cell
« Reply #6 on: February 18, 2014, 02:50:00 pm »
Image of the Day: Apoptotic Cell

As HeLa cells die, they produce characteristic spikes and rounded blebs from their surfaces.

By The Scientist Staff | February 18, 2014

(image at link)
http://www.the-scientist.com//?articles.view/articleNo/39188/title/Image-of-the-Day--Apoptotic-Cell/

Apoptosis is normal, programmed, healthy system cell death. No apoptosis leads to inflammation and cancer.
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AGelbert

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Curcumin and Cancer Prevention and Treatmrent
« Reply #7 on: March 02, 2014, 05:40:26 pm »
http://www.youtube.com/watch?v=RTGXuzlfdp4&feature=player_embedded

Quote
By Dr. Mercola


Cancer is one of the leading causes of death. What if there was a safe, natural herb that could work for nearly every type of cancer? 


According to Dr. William LaValley, who focuses most of his clinical work on the treatment of cancer, curcumin—a derivative of turmeric, and the pigment that gives the curry spice turmeric its yellow-orange color—may fit the bill. It's a natural compound that has been extensively researched, and has been found to have numerous health applications.

Like me, Dr. LaValley was trained in general medicine, but he's devoted a considerable amount of time to understanding the biochemical pathways that can support health nutritionally.

In 1982, he participated in an exchange program to the People's Republic of China, where he got first-hand experience with the ancient practices of traditional Chinese medicine and acupuncture.


"One of the important messages that I learned there was that natural products, natural molecules, from plants and animals that are already available in nature, have been used by the Chinese for at least hundreds, probably thousands of years. That deeply changed my perspective in the world of medicine," he says.


"I came back to medical school, and thereafter, looked at how I could integrate the perspective of conventional pharmaceutical administration as well as natural extract, natural product administration."

Curcumin Has Potent Anti-Cancer Activity



In 2005, he took a 75 percent sabbatical from clinical practice to immerse himself in the science of molecular biology, specifically the molecular biology of cancer. He also devoted approximately 9,000-9,500 hours building a relational database from the PubMed literature about the molecular biology of cancer.

One important lesson he learned through that venture is that the understanding of molecular biology can be applied across a range of diseases and symptoms described in the scientific literature. That knowledge can be applied by searching PubMed and other related databases, looking at the relevant molecular pathways involved.


"In learning the molecular biology of cancer pathways, and in learning that what the evidence actually shows for the effect of natural product extracts on various relevant molecular targets in various cancers,

We see that there's actually quite a large amount of evidence that supports using various molecules, natural products, and pharmaceuticals that are already approved and that have been around for a long time to affect anti-cancer activity along that pathway at that target. That's called molecularly targeted anti-cancer treatment, and it's widely practiced in oncology today.


What's not widely practiced is the use of the natural products for the molecularly targeted anti-cancer activity. I provide that for my patients because the evidence base suggests and supports the use of these treatment recommendations."

Curcumin—A 'Universal' Cancer Treatment?


Interestingly, curcumin appears to be universally useful for just about every type of cancer, which is really odd since cancer consists of a wide variety of different molecular pathologies. You wouldn't necessarily suspect that there would be one herb that would work for most of them. Dr. LaValley explains how he came to this conclusion:


"I went back to the literature and looked at how I can support the decision-making process and the recommendations that I'm making for treatment from the scientific literature, including literature that goes from the treatment of humans with oral products like pharmaceuticals or natural products.


This is where I learned about this molecule called curcumin, all the way down to its use in animals and then its use in test tubes or petri dish... One of the amazing things about curcumin is that this molecule has some profound anti-inflammatory activity and has activity in many molecular targets.


There are molecules that are in the cells, and those molecules interact with each other along certain pathways or tracks. The traffic of that interaction, the signals that are transferred in that trafficking of information in the molecules, presents many different targets or molecular-specific complexes."

As explained by Dr. LaValley, whether the curcumin molecule causes an increase in traffic or activity of a particular molecular target, or a decrease/inhibition of activity, studies repeatedly show that the end result is a potent anti-cancer activity. Furthermore, curcumin does not adversely affect healthy cells, suggesting it selectively targets cancer cells. Research has also shown that it works synergistically with certain chemotherapy drugs, enhancing the elimination of cancer cells.

Curcumin Destroys Cancer in Multiple Ways


Curcumin has the most evidence-based literature1 supporting its use against cancer of any nutrient, including vitamin D, which also has a robust base. Interestingly, this also includes the metabolite of curcumin and its derivatives, which are also anti-cancerous.

Curcumin has the ability to modulate genetic activity and expression—both by destroying cancer cells and by promoting healthy cell function. It also promotes anti-angiogenesis, meaning it helps prevent the development of additional blood supply necessary for cancer cell growth. As for its effect on molecular pathways, curcumin can affect more than 100 of them, once it gets into the cell. More specifically, curcumin has been found to:

Inhibit the proliferation of tumor cells  Decrease inflammation 
Inhibit the transformation of cells from normal to tumor  Inhibit the synthesis of a protein thought to be instrumental in tumor formation 
Help your body destroy mutated cancer cells so they cannot spread throughout your body  Help prevent the development of additional blood supply necessary for cancer cell growth (angiogenesis) 

Why Whole Turmeric Is Ineffective


Unfortunately, while there's some curcumin in whole turmeric, there's not enough in the regular spice to achieve clinically relevant results. The turmeric root itself contains only about three percent curcumin concentration. Another major limitation of curcumin as a therapeutic agent is that it is poorly absorbed. When taken in its raw form, you're only absorbing about one percent of the available curcumin.


"The natural product industry has developed a standard of a 95-percent concentration of curcumin," Dr. LaValleyexplains. "Initially, years ago, that was what we had available for patients. Even at that, taking a 95-percent concentration orally in a capsule, only one percent of that could be absorbed. In order to get amounts of curcumin in the bloodstream that are reasonable to have therapeutic effect, people had to take large amounts of curcumin...


In searching the literature, I found that a way to change that, to dramatically increase the bioavailability, is actually a very simple process of bringing water to a boil, putting those capsules or some dry powder (I use it by the teaspoon), and boiling it for 10 to 12 minutes. That increases the amount of curcumin dissolved in water from that one-percent amount up to 12 percent or so. That amount is a vast number of curcumin molecules that are now in a bioavailable or absorbable form."

However, while this is certainly doable, it's really inconvenient, and great care must be taken to prevent staining your clothes and kitchen surfaces. It's a significant enough problem to have been dubbed "yellow kitchen syndrome," as it's virtually impossible to get the stains out. Turmeric is in fact an excellent dyeing agent for fabrics, rendering them a yellow-orange color.

Convenience and efficiency has driven many of the changes in the forms of curcumin in later years. Because it's a fat-loving or lipophilic molecule, many newer preparations now include some sort of oil or fat, which improves its absorbability and bioavailability. Such preparations typically have seven to eight times higher absorption than the raw, unprocessed 95-percent-concentration of dry powder. There are also newer sustained release preparations, which Dr. LaValley prefers and recommends.

The Connection Between Cancer and Insulin Resistance


If you are overweight, or have high blood pressure, high cholesterol, and/or diabetes, then in all likelihood insulin and leptin resistance is a factor. Insulin and leptin resistance is also a very common factor among cancer patients. From my perspective, a ketogenic diet (with or without intermittent fasting) would be a prudent treatment strategy to resolve that underlying problem. Once you've normalized your insulin and leptin, you don't necessarily need to maintain a ketogenic diet, if you find it too restrictive.


"I agree with you that a ketogenic diet is really appropriate in many cases, probably the significant majority of cases," Dr. LaValley says. "It's been known for probably 80 years or longer that solid tumors, and some of the blood cancers, are sugar-loving. Another term is that they are addicted to sugar.


I use [a] PET scan to demonstrate to patients that here is objective proof that the tumors you have in your body are sugar-avid. They're taking up sugar at a rate much higher than the other regular healthy cells. I want to drive home that message, so that they are motivated to alter their diet to have a low, low carb intake, causing their body to generate additional nutrient supply molecules called ketones...


What that means is that we're trying to provide an anti-cancer antagonistic pressure on the cancer cells by reducing the amount of sugar that's readily available for uptake by reducing the easily available sugar in the diet and compensating for the nutrient reduction and sugar [reduction] by increasing healthy fats."

Cutting Down on Protein May Be Particularly Useful for Cancer Patients


It would also be prudent to assess your protein intake. Many Americans eat far more protein than required for optimal health. The reason for this is because your body can actually use excess protein (you do need some) to stimulate carbohydrate production. Excess protein also stimulates the mammalian target of rapamycin (mTOR) pathways, which are useful for building muscles but can be detrimental when treating cancer, as mTOR is a pathway that increases cellular proliferation. (Interestingly, the pharmaceutical drug Metformin, which has anti-cancer activity, also inhibits mTOR, and it turns out that curcumin has a very similar effect.)

The formula I recommend for assessing how much protein you might need in your diet is from Dr. Rosedale, which calls for one gram of high-quality protein per kilogram of lean body mass, or about half a gram per pound of lean body mass.

As an example, if your body fat mass is 20 percent, your lean mass is 80 percent of your total body weight. So, if your total weight is 200 pounds; you would then divide 160 by 2.2 to convert pounds to kilograms and come up with 72.7 grams of protein. If you are doing vigorous exercises or are pregnant, you can add up to another 25 percent or another 18 grams in this illustration to increase your total to 90 grams per day.

More Information


Dr. LaValley is available for consultation on a wide variety of health challenges, including cancer, and he's licensed to practice medicine in the US and Canada. His medical clinic is located in Chester, Nova Scotia, where he sees patients. Americans can fly there either through Chicago or Newark. His office number is 902-275-4555. He also spends time in Austin, Texas, where he conducts research. When there, he's available to consult for other physicians and their patients.


"For instance, if a patient has pancreatic cancer and the physician wants to implement one of the protocols that I provide, I will do a consultation with that physician's patient and then make recommendations to that physician for implementation,"  he explains. "In that way, patients are able to get it locally without having to travel to Nova Scotia...


It's a challenge right now because there's so much information that's not readily known by so many physicians that they become afraid. I think one of the biggest issues, certainly in US and Canada, is that when a physician wants to administer one of these natural products, or several of them, as well as some of the off-label pharmaceuticals for their anti-cancer usage, they are afraid of recriminations or disciplinary actions.


That is, I think, very unfortunate, because the evidence base does exist for it, and it's consistent with the way that other types of conventional medicine or practice using off-label pharmaceuticals as well. I think that the most important movement that needs to occur is for the patients to recognize their own value in the decision-making process and demand that they have access to these therapeutic choices because they're available, they're supported in the evidence base, and they have the right to ask for them rather than to just accept whatever the physician is otherwise offering in the conventional realm."

http://articles.mercola.com/sites/articles/archive/2014/03/02/curcumin-benefits.aspx

Agelbert NOTE: When my brother in law was dying of colon cancer with mets to the liver last year, he began to take Curcumin massively but it was too late. Curcumin is a strong blood thinner and he began to bleed profusely. This hastened his death.

So Curcumin, like may other natural products out there, is useful in preventing cancer and any condition that a blood clot could cause like an embolism or heart attack. The KEY is prevention. Once the cancer is there, something like concentrated Hemp Oil is in order. Blood thinners are bad news when you are bleeding from cancer produced tumors or sores.

I am not a doctor; I just read a lot and like to share my experience. Use discretion.
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AGelbert

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Re: Cancer
« Reply #8 on: March 03, 2014, 01:18:01 am »
I'm sorry to hear about your niece. So young!  :( And yes, it seems cancer cells absolutely love sugar. I stopped putting sugar in my coffee seven years ago. My health has improved because of it.  8)
I'm convinced sugar is far more dangerous to human health and a bigger culprit in high blood pressure than salt even though salt in excess can be damaging.

By the way, my SPEP/UPEP came out normal. So far, so good.
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What Happens When You Pee in the Pool? April 26, 2014   

By Dr. Mercola

One in five Americans admit they have peed in a pool, and among Olympic swimmers, the practice is so widespread that a former US National team member said nearly 100 percent of competitive swimmers pee in the pool… regularly.1

Swimming in a urine-contaminated pool is certainly not the most pleasant thought, but is it really so bad?

Olympic swimmer Michael Phelps doesn't think so, and famously said that "chlorine kills it [urine]," making peeing in the pool a non-issue. But it's not the urine itself that you need to worry about.

Urine is virtually sterile when it leaves your body, so it doesn't pose the risk of causing illness the way fecal matter in a pool does. In fact, urine is a valuable source of nutrients that is now being used as an effective and natural fertilizer.

So it's not the urine that is the problem… it's what happens when urine mixes with pool chemicals, including chlorine, that is catching researchers' attention.

Peeing in the Pool Creates a Chemical Warfare Agent  :o  :P

Highly toxic disinfection byproducts (DBPs) form from reactions between pool disinfectants and organic matter, including hair, skin, sweat, dirt and… urine. In a new study, researchers mixed uric acid from human urine with chlorine and found it creates two DBPs: cyanogen chloride (CNCl) and trichloramine (NCl3).2


The former, CNCI, is classified as a chemical warfare agent and is a known toxicant to your lungs, heart, and central nervous system. NCl3 is linked to lung damage.

As for how dangerous this is, practically speaking, the researchers found that, in a worst-case scenario, urine in a pool might lead to about 30 parts per billion (ppb) of cyanogen chloride, which is well below the 70 ppb used as the maximum cyanogen concentration allowed in drinking water, according to the World Health Organization (WHO).3 

Cyanogen chloride leads to coma, convulsions and death only at much higher levels (about 2,500 ppb),[size=12pt] an amount that would be difficult, and probably impossible, to generate in a typical swimming pool from urination alone.[/size]4 This doesn't mean that smaller doses are "safe," however, as DBPs have been linked to serious health problems at levels found in swimming pools.

According to the study researchers, since urinating in a pool introduces uric acid that will lead to the formation of a poison when it interacts with chlorine, it should be avoided:

" …uric acid chlorination may account for a large fraction of CNCl formation in swimming pools. Moreover, given that uric acid introduction to pools is attributable to urination, a voluntary action for most swimmers, these findings indicate important benefits to pool water and air chemistry that could result from improved hygiene habits on the part of swimmers."
Spending Just 40 Minutes in a Chlorinated Pool May Lead to DNA Damage
If you've ever wondered if the chlorine in a swimming pool poses a health risk, you'll find it unsettling to know that the DBPs created by chlorine reactions are far more dangerous. In fact, when researchers measured evidence of genotoxic (DNA damage that may lead to cancer) and respiratory effects on swimmers who swam in a chlorinated pool for just 40 minutes, they found:5
•Increased micronuclei in blood lymphocytes, which are associated with cancer risk
•Urine mutagenicity, a biomarker of exposure to genotoxic agents
•An increase in serum CC16, which suggests an increase in lung epithelium permeability


Adding chlorine to a swimming pool results in the formation of hundreds of DBPs because of the organic matter in the water. The researchers found that total concentrations of four DBPs (trihalomethanes (THMs)) were seven times higher in exhaled breath after swimming than they were before.  :P They noted:

"Our findings support potential genotoxic effects of exposure to DBPs from swimming pools. The positive health effects gained by swimming could be increased by reducing the potential health risks of pool water."

DBPs in Swimming Pools Are Linked to Cancer

It's known that trihalomethanes (THMs), one of the most common DBPs, are Cancer Group B carcinogens, meaning they've been shown to cause cancer in laboratory animals. They've also been linked to reproductive problems in both animals and humans, such as spontaneous abortion, stillbirths, and congenital malformations, even at lower levels.

It's not only swimming pools that are problematic, as DBPs also exist in chlorinated drinking water. Ingesting chlorinated water with levels of DBPs common in many industrialized countries has been linked to an increased risk of bladder cancer.6

However, when researchers also looked at exposure to DBPs through your skin and via inhalation (such as occurs while showering, bathing and swimming in pools), it was found to be an even greater risk than drinking water.7

Furthermore, people who frequent swimming pools have an increased risk of bladder cancer compared to those who do not,8 and DBPs have even been suggested as partially responsible for the increased risk of melanoma cancer among swimmers.9

According to one study published in the Journal of Environmental Sciences,10 the cancer risk of DBPs (in this case THMs) from various routes in descending order was:
1.Skin exposure while swimming
2.Gastrointestinal exposure from tap water intake
3.Skin exposure to tap water
4.Gastrointestinal exposure while swimming



The cancer risk from skin exposure while swimming comprised over 94 percent of the total cancer risk resulting from being exposed to THMs! The authors even went so far as to conclude that swimming in a chlorinated pool presents "an unacceptable cancer risk."


DBPs Pose Risks of Allergies, Asthma, and Other Health Problems

Most public pools are overloaded with chlorine, as the well-intentioned people who maintain public pools overly shock them with chlorine to make sure bacteria and other organisms get snuffed out quickly. But even the swimming pool in your backyard could be toxic if you treat it with chlorine – even if you know no one is using it to pee in.

Remember, any organic matter – including hair, skin, sweat, and dirt – can react with chlorine to create DBPs. So if you use chlorine, it's going to be virtually impossible to avoid some exposure. Many studies have pointed out the health risks associated with swimming in chlorinated water, and many of these are related to toxic DBPs:
•Swimming instructors are more than twice as likely to suffer frequently from sinusitis or sore throat, and more than three times as likely to have chronic colds, than pool workers with less DBP exposure, such as catering employees or receptionists.11
•Compared to the general population, pool workers with high levels of exposure were at a 40 percent greater risk for tightness of the chest and were over 700 percent more likely to suffer breathlessness while walking.12
•DBPs may cause weakening of your immune system, disruptions to your central nervous system, damaging effects to your cardiovascular system, unhealthy functioning of your renal system and harmful impacts to your respiratory system.

Should You Avoid Swimming Pools?  ???

The risk of DBP exposure from swimming pools is real, but it doesn't necessarily mean you have to give up swimming. Swimming in an ocean    ;D is an excellent alternative,  as is swimming in a lake or other natural body of water. You can also find a way to keep your pool clean from bacteria, algae, and other organisms without the use of dangerous chemicals, such as choosing a saltwater pool. 

One of the best solutions is NOT to chlorinate your pool and just use a maintenance "shock" treatment every five or six days, which will kill the algae buildup. The shock treatment volatilizes in about 24-48 hours and gives you a several-day window in which you can safely use your pool. You can also reduce the amount of organic material you bring into the pool, and thereby the amount of DBPs created, by showering prior to entering and teaching your children    not to urinate in the water. You can also use ozone, which also oxidatively destroys the pool pathogens and lowers the need for chlorine.

This will be difficult if you're visiting a public swimming pool or waterpark, however. Surveys show that 35 percent of Americans say they do not shower prior to entering a pool. Finally, because DBPs exist in all chlorinated water, I recommend installing water filters that remove chlorine for both your shower/bath and your kitchen tap.

http://articles.mercola.com/sites/articles/archive/2014/04/26/urine-chlorinated-pool.aspx
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AGelbert

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Water-based 'engine' propels tumor cells through tight spaces in the body

Johns Hopkins researchers have discovered a new mechanism that explains how cancer cells spread through extremely narrow three-dimensional spaces in the body by using a propulsion system based on water and charged particles.
    

The finding, reported in the April 24 issue of the journal Cell, uncovers a novel method the deadly cells use to migrate through a cancer patient's body. The discovery may lead to new treatments that help keep the disease in check. The work also points to the growing importance of studying how cells behave in three dimensions, not just atop flat two-dimensional lab dishes.

Based on such lab dish studies, cancer researchers had concluded that tumor cells require actin and other proteins to form arm-like extensions to "crawl" across the flat surfaces. This type of travel was believed to be the primary means of how cancer spreads within a patient, a process called metastasis. Based on this conclusion, researchers have been working on ways to disable actin and its molecular helpers, hoping this can keep cancer from spreading.

But in a study published in 2012, a Johns Hopkins team led by Konstantinos Konstantopoulos, chair of the Department of Chemical and Biomolecular Engineering, found that tumor cells could move through narrow spaces without using actin and its biochemical partners.

"That was a stunning discovery, not in line with the prevailing beliefs about how cells migrate," Konstantopoulos said. "So we wanted to figure out exactly how the tumor cells were able to move through these spaces without relying on actin."

He collaborated with Sean X. Sun, a Johns Hopkins associate professor of mechanical engineering with experience in math modeling and physics at microscopic levels.

"The mystery we needed to solve," Sun said, "was how the cells in these confined spaces could still move when you took away their usual 'engine,' the actin."



Kostantopoulos said Sun and Hongyuan Jiang, a postdoctoral fellow working in Sun's lab, "came up with a phenomenal mathematical model that provided insights into how the cells might use a different system to travel." Then Konstantopoulos and other team members, including Kimberly Stroka, a postdoctoral fellow in his own lab, used a microfluidic lab-on-a-chip and imaging techniques to conduct experiments establishing the new mechanism of migration proposed by Sun and Jiang's model. The tests utilized human and animal cancer cells. Stroka and Jiang were designated co-lead authors of the resulting journal article.

As reported in the article, the tumor cells' new "engine" turned out to be a combination of sodium-hydrogen ions, cell membrane proteins called aquaporins, and water.

                                                                 Aquaporin

The researchers found that within tight spaces, cancer cells create a flow of liquid that takes in water and ions at a cell's leading edge and pumps them out the trailing edge, propelling the cell forward. In the actin-dependent migration model, the cell is pushed forward by the biochemical equivalent of a boat engine. The water-based mechanism, the researchers said, more closely resembles the way a sailboat is thrust ahead by gusts of wind. The team called this mechanism the Osmotic Engine Model.

"This discovery is important because it reveals one reason why some diseases like cancer don't always respond to certain treatments," Konstantopoulos said. Sun added, "It's because these diseases have redundant mechanisms—more than one method—for migrating through the body."

Agelbert Note: This discovery is also important because it underlines the vital importance of maintaining a proper level of hydration in the human body. DEHYDRATION will slow immune system response but WON'T slow the cancer mets!  :o :P This is another good reason to stay properly hydrated.


 Explore further: Cancer cells don't take 'drunken' walks through the body

Journal reference:  Cell search and more info website

Provided by  Johns Hopkins University

graphics and video at link


http://medicalxpress.com/news/2014-04-water-based-propels-tumor-cells-tight.html

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AGelbert

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Agelbert NOTE: interesting article on this new test WITH IMMINENT FDA approval that MAY avoid the cost (and risk from intestinal perforation) involved in a colonoscopy.  ;D I am not sure yet if that means EXAS is a buy but I'm watching it...  ;)

Cologuard Will Dominate Its Addressable Market


 May. 19, 2014 10:59 AM ET  |  54 comments |  About: EXACT Sciences Corporation (EXAS) 


Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.   
Summary

•A recent expert interview with a gastroenterologist indicated that Cologuard has significant market potential.

•Up to 30% of FIT patients would not be suitable for Cologuard, due to the need for colonoscopies roughly every 3-5 years anyway.

•Outside of those patients, Cologuard will own its addressable market and be rapidly adopted by physicians.

•Eventual penetration into the 70% range of this market is reasonable, and even at $300/test, Exact Sciences is undervalued.

http://seekingalpha.com/article/2225513-cologuard-will-dominate-its-addressable-market

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AGelbert

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Re: Cancer
« Reply #14 on: July 04, 2014, 08:10:15 pm »
Does Sugar Overconsumption Really Cause Cancer and Contribute to Heart Disease? ???

Sugar overconsumption might cause cancer and contribute to heart disease, research suggests. This is thought to be the result of extra stress put on the body during the metabolizing of fructose, or the sugar found in certain plants. Unlike the carbohydrates found in vegetables and starches that are metabolized by all of the body’s cells, fructose is metabolized only by the liver. The increase in metabolizing blood sugar is thought to cause the cell mutations that result in cancer and raise the levels of triglycerides, or fat, in the bloodstream, which can cause heart disease.

More about sugar:

•The average American is estimated to consume about 90 pounds (40.82 kg) of sugar each year.

•There are about 10 teaspoons (40 g) of sugar in an average can of soda, which is nearly twice the amount of sugar that health experts recommend consuming in a day.

•Lower-income people consume the most calories from sugar, at roughly 15% of their daily intake. People in the highest income bracket consume only about 11% of their daily calories from sugar.

http://www.wisegeek.com/does-sugar-overconsumption-really-cause-cancer-and-contribute-to-heart-disease.htm
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